Dsm IP Assets B.v.

Nestec S.a.

Goede Schueler

Christof Wehrli

Daniel Raederstorff

Regina Goralczyk

Ann Fowler

Antoine De Saizieu

Claus Kilpert

Joseph Schwager

Peter Weber

Swen Wolfram

Hasan Mohajeri

Ying Wang-Schmidt

Bernd Mussler

Sandra Renata Teixeira

Ying Wang Schmidt

Antione De Saizieu

Daniel D'Orazio

The present invention refers to tricyclic diterpenes and their derivatives of the formulae (I) and (II), wherein Ris hydrogen or C-alkyl; Ris hydroxy, C-acyloxy, hydroxymethyl, 1,3-dihydroxypropyl or C-alkyl; Rand Rindependently from each other are hydrogen, hydroxy, hydroxymethyl, C-acyloxy or C-alkoxy; Ris C-alkyl, hydroxymethyl carboxy or methoxycarbonyl; Ris hydrogen, hydroxymethyl, methoxy, oxo or C-acyloxy; Ris hydrogen, or Rand Rtaken together are &#x2014;CH&#x2014;O&#x2014; or &#x2014;O&#x2014;CH&#x2014;; or Rand Rtaken together are &#x2014;CO&#x2014;O&#x2014;, &#x2014;O&#x2014;CO&#x2014;, &#x2014;CH&#x2014;O&#x2014; or &#x2014;O&#x2014;CH&#x2014;; Ris hydrogen, or Rand Rtogether to form a bond; Rand Rindependently from each other are C-alkyl, carboxy, x-hydroxy-Cx-alkyl (with x being an integer from 1 to 6), or C-alkoxycarbonyl with the proviso that at least one of Rand Ris C-alkyl; Rand Rare both hydrogen or Rand Rtogether are oxo, with the further proviso for formula (I) that if Ris hydroxy Ris C-alkyl, for use as medicaments for the treatment of a disorder connected to impaired neurotransmission, as well as to dietary and pharmaceutical compositions and their uses.

Dietary and pharmaceutical compositions containing tricyclic diterpenes and their derivatives and their uses

The present invention relates to novel composition for the treatment, co-treatment or prevention of inflammatory disorders comprising an effective amount of carnosic acid 12-methylether.

Compositions

The present invention refers to tricyclic diterpenes and their derivatives of the formulae (I) and (II), wherein Ris hydrogen or C-alkyl; Ris hydroxy, C-acyloxy, hydroxymethyl, 1,3-dihydroxypropyl or C-alkyl; Rand Rindependently from each other are hydrogen, hydroxy, hydroxymethyl, C-acyloxy or C-alkoxy; Ris C-alkyl, hydroxymethyl carboxy or methoxycarbonyl; Ris hydrogen, hydroxymethyl, methoxy, oxo or C-acyloxy; Ris hydrogen, or Rand Rtaken together are &#x2014;CH&#x2014;O&#x2014; or &#x2014;O&#x2014;CH&#x2014;; or Rand Rtaken together are &#x2014;CO&#x2014;O&#x2014;, &#x2014;O&#x2014;CO&#x2014;, &#x2014;CH&#x2014;O&#x2014; or &#x2014;O&#x2014;CH&#x2014;; Ris hydrogen, or Rand Rtogether form a bond; Rand Rindependently from each other are C-alkyl, carboxy, x-hydroxy-Cx-alkyl (with x being an integer from 1 to 6), or C-alkoxycarbonyl with the proviso that at least one of Rand Ris C-alkyl; Rand Rare both hydrogen or Rand Rtogether are oxo, with the further proviso for formula (I) that if Ris hydroxy Ris C-alkyl, for use as medicaments for the treatment of a disorder connected to impaired neurotransmission, as well as to dietary and pharmaceutical compositions and their uses.

Dietary and pharmaceutical compositions containing tricyclic diterpenes and their derivates and their uses

The present invention relates to the use of a compound as effective agent for the prevention or treatment of diabetes mellitus in a mammal. Said compounds being selected from the group of phthalide derivatives and exhibit excellent blood glucose lowering effects and thus are effective agents in the prevention or treatment of diabetes mellitus in mammals.

Use of phthalide derivatives for the treatment of type 2 diabetes mellitus

The present invention refers to carnosol and rosmanol for use (as medicament) in the treatment of a disorder connected to reduced neurotransmission, cognitive dysfunction and/or symptoms caused by headache and/or migraine, as well as to dietary and pharmaceutical compositions and their uses.

Dietary and pharmaceutical compositions containing carnosol and/or rosmanol and their uses

The present invention relates to new methoxylated aromatic compounds. It also relates to novel compositions comprising methoxylated aromatic compounds as well as to the use of these compositions as a medicament, in particular as a medicament for the treatment, co-treatment or prevention of inflammatory disorders.

Nutraceutical and pharmaceutical compositions and use thereof for the treatment, co-treatment or prevention of inflammatory disorders

The present invention refers to coumarin ethers of the formula (I), wherein Ris H, OH or (E)-3-methyl-but-2-enyl, Ris selected from the group consisting of methyl, 3-(4,5-dihydro-5,5-dimethyl-4-furanon-2-yl)-2-(E/Z)-butenyl, (E/Z)-3,7-dimethylocta-2,6-dienyl, 7-hydroxy-3,7-dimethyl-2-octen-6-on-yl and (E/Z,E/Z)-11-acetyl-oxy-3,7,11,11-tetramethyl-undeca-2,7-dien-10-on-yl, Ris H, Rand RO together for the group &#x2014;O&#x2014;C(C(&#x2550;CH)CH)H&#x2014;CH&#x2014;O&#x2014; or the group &#x2014;C(H)&#x2550;C(H)&#x2014;C(CH)&#x2014;O&#x2014; or RO and Rtogether form the group &#x2014;O&#x2014;C(H)(C(CH)(H)&#x2014;O&#x2014;C(O)CH)&#x2014;CH&#x2014;, preferably to obliquin, for use as medicaments, especially for the treatment and/or prevention of disorders connected to impaired neurotransmission, as well as to dietary and pharmaceutical compositions and plant extracts containing such coumarin ethers and their uses.

Growing community of inventors

Eimeldingen, Germany

Goede Schueler