Kuraray Co., Ltd.

Corning Incorporated

Public University Corporation Yokohama City University

Nagoya University

University of Tsukuba

Go Tazaki

Motohiro Fukuda

Hideki Taniguchi

Hitoshi Tsuruta

Taiji Nishi

Masaya Hosoda

Yun-Wen Zheng

Toshiaki Hasegawa

Yoko Itchoda

Tomoko Kosaka

Masayuki Takahashi

Hideaki Suzuki

Yoko Ejiri

Hiroaki Suzuki

Satoru Ayano

Junji Fukuda

Keisuke Sekine

Hideaki Takeda

Taisuke Kamada

Kishio Furuya

Masahiro Sokabe

Yuji Morimoto

Michio Yazawa

Kentaro Okamura

Masatoshi Hashimoto

Takahisa Anada

Hideki Kuramitsu

Kensuke Kamoshida

Provided are a polyamide resin composition prepared by blending a polyamide resin (A) and a polyalcohol (B), wherein the proportion of the number of the amide groups to the number of the carbon atoms in the polyamide resin (A) is 0.080 to 0.140 and the blending amount of the polyalcohol (B) is 1 to 10 parts by mass relative to 100 parts by mass of the polyamide resin (A); and a molded article of the resin composition.

Polyamide resin composition and molded article thereof

There is provided a multilayered tube for transporting liquid chemicals containing an outermost layer and an innermost layer, the innermost layer containing a polyamide (A), an impact modifier (B), and a carbon nanotube (C), wherein the number of projections each having a height of 5 &#x3bc;m or more and a longitudinal width of 20 &#x3bc;m or more, which are present on the surface of the innermost layer, is 2 or less per 1 mmof surface area; and the number of agglomerates each having a longitudinal width of 5 &#x3bc;m or more, which are present in the cross section of the innermost layer, is 15 or less per 1 mmof cross-sectional area. There is also provided a polyamide resin composition constituting the innermost layer of the multilayered tube for transporting liquid chemicals.

Multilayered tube for transporting liquid medicine and polyamide resin composition

To provide a cell culture kit including cultured living cells of various donors, and a manufacturing method thereof. The cell culture kit includes a culture plate and living cells cultured thereon. The culture plate includes a plurality of microchambers () and living cells derived from various donors are adhered to surfaces of the plurality of microchambers (). Specifically, living cells D, D, and Dderived from various donors are adhered to the plurality of microchambers (). In each microchamber (), living cells derived from one donor or living cells derived from various donors may be cultured. The living cells derived from various donors are adhered and cultured in the cell culture kit as a whole, which makes it possible to provide a cell culture kit to conduct a test using cells derived from various donors.

Cell culture kit, screening method, and method of manufacturing cell culture kit

Provided are a method capable of evaluating adherent cells under an environment similar to an in vivo environment by a culture method similar to a two-dimensional culture, and applications thereof. An adherent cell culture method uses, as a culture chamber (), a chamber in which two or more culture spaces each having an equivalent diameter (D) that is 1 to 5 times the diameter of a desired spheroid and each having a height (H) that is 0.3 to 5 times the equivalent diameter are arranged and a surface of each of the culture spaces has a water contact angle of 45 degrees or less. Spheroids of adherent cells are cultured in the respective culture spaces () arranged in the culture chamber ().

Adherent cell culture method

Provided is a method that achieves control of embryoid body size and can induce differentiation in a state where the embryoid body size is controlled, by using a cell culture chamber having a plurality of microchambers formed therein. A culture method for causing differentiation of pluripotent mammalian cells uses a cell culture chamber () having a plurality of microchambers () formed on a culture surface. The cell culture chamber () has a culture surface formed of spaces in which the microchambers () have a space structure with a height of 10 &#x3bc;m to 500 &#x3bc;m and a bottom area of 100 &#x3bc;mto 1 mm. The culture method for causing differentiation of pluripotent mammalian cells includes culturing pluripotent mammalian cells to obtain a cell population at least partially differentiated into endoderm lineage cells, by using the cell culture chambers ().

Method for differentiating pluripotent mammalian stem cells into a population of hepatic cells in a microchamber

A multilayered tube for transporting fuel including an innermost layer (A), an outermost layer (B) and an intermediate layer (C), characterized by that: the innermost layer (A) and the outermost layer (B) include a resin composition including 40 mass % or more of semi-aromatic polyamide; a flexural modulus of a material constituting the intermediate layer (C) measured according to ISO 178 is 800 MPa or less; and it is used in an environment in which both the innermost layer (A) and the outermost layer (B) are contacted with biodiesel fuel. In addition, a fuel pump module including the multilayered tube for transporting fuel and a method for using them.

Multilayer tube for fuel transportation, fuel pump module provided with same, use of same, and use of fuel pump module

Provided is a cell culture method whereby an in vivo function can be sustained over a long period of time and culture can be conducted using the minimum number of cells required. The cell culture method includes culturing undifferentiated cells in a layered state in a partitioned micro-space and obtains differentiated cells. When screening a pharmaceutical agent, undifferentiated cells capable of differentiating into liver cells, intestinal epithelial cells, nerve cells, myocardial cells and vascular endothelial cells are preferred. Particularly, in the prediction of pharmacokinetics or the like for humans, human cells are preferred.

Cell culture of fetal liver in layered state in a partitioned micro-space

To provide a cell culture method capable of sustaining in-vivo functions for a long time by suppressing dedifferentiation. A cell culture method in accordance with the present invention is to culture cells in a multi-layered state in a minute partitioned space and to obtain a tissue structure having a function resembling an in-vivo function. When the cells are mammary gland epithelial cells, a hollow acinus-like structure can be formed. The minute partitioned space is particularly preferably a micro container in a cell culture container having a plurality of such micro containers on the surface.

Mammary gland epithelial cell culture

To provide a cell culture chamber capable of reproducing a cell function in vivo, and a method of producing the same. The cell culture chamber according to the present invention has a concave-convex pattern formed on the surface on which cells are cultured. A concave portion of the concave-convex pattern includes cell culture portions and micro flow channels communicating with the cell culture portions. The bottom surface of each of the cell culture portions has a width 1.0 to 20 times an equivalent diameter of each of the cultured cells. A cell adhesion-inducing substance is formed only on the bottom surface and the side walls of the concave portion.

Cell culture container and method of producing the same

An object of the present invention is to provide a cell culture chamber with which the survival rate of cells to be cultured can be increased, and a method of producing the same. A cell culture chamber according to the present invention includes a mass of projections formed of a plurality of microprojections 1 formed on a surface on which cells are cultured. The width or diameter of each of the microprojections 1 is in a range of 20 nm to 3 &#x3bc;m, and the aspect ratio of each of the microprojections is in a range of 0.2 to 3.0. Thus, there can be provided a cell culture chamber most suitable for the adhesion and differentiation/proliferation of cells to be cultured.

A cell culture chamber and a cell culture method that are capable of effectively constructing an intercellular network in a culture space are provided. A cell culture chamber ()according to the present invention is a cell culture chamber ()including a plurality of microchambers () formed on a surface thereof, characterized in that convex portions (side walls) that partition the microchambers () adjacent to each other are formed to prevent cells from being adhered to upper surfaces of the convex portions. Consequently, cells can be cultured exclusively within the microchambers (), and an intercellular network can be constructed effectively.

Cell culture container and cell culture method

Provided is an electrochemical sensor device capable of micromachining a channel while maintaining its measurement sensitivity and of reliably quantitating an analyte in a trace amount of a sample. An electrochemical sensor device includes: a channel portion formed in a substrate; and working electrodes for subjecting an analyte in a solution flowing in the channel portion to electrochemical measurement, the electrochemical sensor device includes a plurality of measuring portions individually provided with the working electrodes, and each of the working electrodes has a plurality of conductive protrusion portions formed to protrude from a bottom surface of each of the measuring portions.

Growing community of inventors

Tsukuba, Japan

Go Tazaki