Yamanouchi Pharmaceutical Company Ltd.

Go Ohtani

Hiroshi Maeda

Masayoshi Aruga

Jun Sekino

Toshimitsu Konno

Shoji Yokota

Mitsugu Kobayashi

Katayasu Ogawa

A lyophilized pharmaceutical composition comprised of a neocarzinostatin derivative having the formula (SMA)-(NCS)-(SMA), is made by a method including dissolving the neocarzinostatin derivative and stabilizing agent comprising at least one saccharide selected from the group consisting of monosaccharides, disaccharides and dextran in an aqueous buffer solution having a pH ranging from about 7.5 to about 9.5, the stabilizing agent being present in an amount by weight (titer) which is at least equal to that of the neocarzinostatin derivative, to provide a solution; adjusting the pH of the solution to provide a pH-adjusted solution having a pH of about 8.0.+-.0.5; sterilizing the pH-adjusted solution by filtration to provide a sterilized solution; and lyophilizing the sterilized solution.

Lyophilized pharmaceutical composition of neocarzinostatin derivative

An injectable composition of nicardipine hydrochloride comprising an aqueous nicardipine hydrochloride solution containing 2-7 w/v % of polyhydric alcohol. This injectable composition can maintain its desired concentration and can be stably stored for a long period of time.

Injection of nicardinpine hydrochloride and process for the production

Growing community of inventors

Tokyo, Japan

Go Ohtani