Centro De Ingenieria Genetica Y Biotecnologia

Gloria Véliz Rios

Luis Javier González López

Lila Rosa Castellanos Serra

Jorge Victor Gavilondo Cowley

Mónica Bequet Romero

Manuel Selman-Housein Sosa

Eduardo Martinez Diaz

Caridad Anais Gasmuri González

José Garcia Suárez

Raúl Gómez Riera

Maria Del Carmen Abrahantes Pérez

Jesús Reyes González

The present invention is related to a composition capable of inhibiting the growth of tumoral cells of different histological origins and of activated endothelial cells. The components of said compositions are polypeptide fragments of the serralisins, corresponding to the C-terminal fragment, from the internal metionine trough the end of the molecule, which could be combined among them and optionally with the prodigiosins that potentiate the antitumoral effect of the composition. The prodigiosins in the composition could be at a concentration of 0.1-100 nM. The anti-proliferative action of this composition is mediated by apoptotic mechanism. It's 'in vivo' administration has antitumoral, antiangiogenic and protective effect against malignant tumors.

Pharmaceutical composition containing polypeptide fragments of serralysins

Growing community of inventors

Cuidad de la Habana, Cuba

Gloria Véliz Rios