University of South Florida

Glenn Roma

Edward Turos

Burt E Anderson

Ryan Scott Cormier

John C Thomas

Rebecca J Kapolka

species are facultative intracellular pathogens responsible for a range of diseases in animals and in humans. A selection of N-acyl ciprofloxacin analogues, chemically synthesized from ciprofloxacin, have been tested in vitro for activity againstspecies as models for therapeutic development. Ninestrains, including five of, two of, and one each ofand, have been tested for susceptibility to different N-acyl ciprofloxacin derivatives. Several techniques have been used to test the in vitro antibacterial activity of the derivatives. Seven of them, labeled RC4-125, RC4-143, RC4-147, RC5-28, RC5-29, RC5-32 and RC5-69 showed significant intracellular anti-activity. These synthetically derived N-acyl ciprofloxacin derivatives may be useful in the therapeutic treatment of infections caused by

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Tampa, FL, United States of America

Glenn Roma