Scios Inc.

Novartis Ag

Achaogen, Inc.

Glenn McEnroe

Sundeep Dugar

Sarvajit Chakravarty

Martin Sheringham Linsell

James Bradley Aggen

Frederick Cohen

Xiaodong Lin

Paola Dozzo

Mika Lindvall

Heinz Ernst Moser

Micah James Gliedt

Aregahegn Yifru

Darin James Hildebrandt

Qing Lu

Alison Murphy

Qingming Zhu

Meiliana Tjandra

Robert Lowell Simmons

Timothy Robert Kane

Folkert Reck

Anthony Casarez

Virender Singh Aulakh

Brian D Patterson

Ramesh Annasaheb Kasar

Aurelia Conte

Babu J Mavunkel

John J Perumattam

Gregory R Luedtke

Xuefei Tan

Jonathan Axon

This invention pertains generally to antibacterial compounds of Formula I, as further described herein, and pharmaceutically acceptable salts and formulations thereof. In certain aspects, the invention pertains to methods of using such compounds to treat infections such as those caused by Gram-negative bacteria.

Monobactam organic compounds for the treatment of bacterial infections

Antibacterial compounds of formula (I) are provided: as well as stereoisomers and pharmaceutically acceptable salts thereof; pharmaceutical compositions comprising such compounds; methods of treating bacterial infections by the administration of such compounds; and processes for the preparation of such compounds.

Antibacterial agents

Quinazoline derivatives have the formula:  Such compounds are useful in pharmaceutical compositions and methods of treating conditions characterized by enhanced TGF&#x3b2; activity.

Quinazoline derivatives as medicaments

Compounds in which a pyrimidine nucleus is bridged at the 5 and 6 position and are further substituted at positions 2 and 4 with substituents comprising aromatic moieties are useful in treating subjects with rheumatoid arthritis ameliorated by inhibition of TGF&#x3b2; activity.

Bi-cyclic pyrimidine inhibitors of TGF&#x3b2;

Certain compounds which contain a piperidine moiety flanked by aryl groups are inhibitors of p38-&agr; kinase and thus useful in the treatment of a variety of conditions characterized by inappropriate p38-&agr; kinase activity.

Piperidine/piperazine-type inhibitors of p38 kinase

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San Mateo, CA, United States of America

Glenn McEnroe