Baxter Travenol Laboratories, Inc.

Baxter International Inc.

Other

Glenn L Slater

Brian D Zdeb

David A Winchell

Thomas A Fowles

Gerhard H Weiler

Lawrence Pete Kitterman

Robert Turoff

Steve Pearson

Baxter International, Inc

A medical fluid administration set is disclosed which may be used for the passive reconstitution and delivery of a drug or other beneficial agent with liquid flowing through the administration set. A receptacle mounted in the administration set is adapted for receiving a cartridge containing the beneficial agent. Also disclosed is an adapter for connecting the cartridge and the receptacle and an air flask within the administration set.

Passive drug delivery system

Adapter for passive drug delivery system

A housing is provided for insertion in an intravenous delivery system including a fluid source and a fluid conduit. The housing is adapted for receiving a beneficial agent to be mixed with fluid flowing through the fluid conduit. The beneficial agent is reconstituted within the housing, eliminating the need for manual reconstitution. The housing may comprise a separate receptacle and cartridge in which the receptacle is manufactured 'in-line' in an administration set and the cartridge is adapted for receiving a beneficial agent. In one embodiment of the invention, the cartridge is a standard drug vial.

Housing enabling passive mixing of a beneficial agent with a diluent

A one-piece integral plastic container is disclosed which has an outer closure or overcap removable along a frangible line of weakness, and a separately-formed inner closure that is maintained in sterile condition by the outer closure until the container contents are dispensed. The inner closure comprises a tubular member inserted in fluid-tight relationship within the container neck after the container body and neck are molded, but prior to formation of the outer closure. The tubular member thus provides the dispensing outlet for the container and is maintained in sterile condition by the overcap which encloses it.

Method of making a bottle closure

A container which includes body, neck and cover portions of one-piece plastic construction and a line of weakness defined between the neck and cover portions to permit selective separation of the cover from the neck, further includes an inner closure carried by and removable with the cover portion to prevent spillage of the container contents upon opening of the container. The inner closure is disposed to seal the neck below the line of weakness to isolate the contents of the container from the area of the line of weakness. When the container is heat sterilized, means is provided associated with the chamber defined by the cover and closure to prevent collapse of the cover during the post heat-sterilization cooling cycle. The associated means includes structure to provide moist air in the defined chamber during heating of the container without endangering the sterility of the container contents or nullifying the advantage of the inner closure.

Sterilizable container with inner closure and collapse-resistant cover

Bottle

Bottle closure

Growing community of inventors

Ingleside, IL, United States of America

Glenn L Slater