University of Utah Research Foundation

The State University of New York

Echelon Biosciences Incorporated

Anika Research, Inc.

Deuteria Biomaterials, LLC

Frontier Scientific, Inc.

Glycomira Therapeutics, Inc.

Other

University of Tennessee Research Foundation

Anika Therapeutics, Inc.

Symic Holdings, Inc.

Glenn D Prestwich

Thomas P Kennedy

David A Swann

Yanchun Liu

Jianxing Zhang

Jing-Wen Kuo

Narayanam Rao

Xiao Zheng Shu

Won Yong Lee

Wanjian Jia

Kelly R Kirker

Xiaoyu Xu

Siam Oottamasathien

Colin Ferguson

Jerry Charles Bommer

Yi Luo

Charles Testa

Tara Pouyani

Lindsi McCoard

Joseph Cappello

Barry S Coller

John Eric Paderi

Guanghui Yang

Gabor G Tigyi

Katherine Allison Stuart

Hamidreza Ghandehari

Russell Morris Condie

Honglu Zhang

Natalya Y Rapoport

Justin Savage

Joanna Gajewiak

Mark Martin Jensen

Damian Madan

Steven D Gray

Janice Gray, Legal Representative

Siam Oottamasathein

Hao Li

Beth E Drees

Paul O Neilsen

Leena Chakravarty

Michael J Mostert

Julia Chen

Siam Oottamasathien, Viii

Abigail Pulsipher

Dale M Marecak

Harsha Kabra

Elvis Ikwa

Guowei Jiang

Lindsi M Roundy

Beth Drees

Paul Neilsen

Xiayou Xu

Justin Rodney Savage

Rush Lloyd Bartlett Ii

Described herein are methods for reducing or maintaining the size of a tumor in a subject, where the method involves exposing the tumor to ionizing radiation and administering to the subject a modified hyaluronan or a pharmaceutically acceptable salt or ester. The use of the modified hyaluronan enhances or potentiates the effect of ionizing radiation used in cancer treatment. Additionally, the methods described herein prevent or reduces tumor regrowth in the subject after exposing the tumor to ionizing radiation and administration of the modified hyaluronan to the subject.

Methods for potentiating cancer treatment using ionizing radiation

Provided herein are synthetic bioconjugates comprising collagen-binding peptides covalently bound to chemically modified glycan backbones, compositions containing the same, and uses thereof.

Bioconjugates with chemically modified backbones

Described herein are methods for preventing a serious health consequence and/or tissue damage in a subject after the subject has been exposed to ionizing radiation and/or chemotherapy. The methods involve administering to the subject a sulfated polysaccharide or the pharmaceutically acceptable salt or ester thereof after the subject has been exposed to ionizing radiation and/or chemotherapy. The methods described herein are most beneficial to cancer patients who suffer from mucositis after exposure to ionizing radiation.

Methods for preventing a serious health consequence and/or tissue damage after exposure to ionizing radiation and/or chemotherapy

Described herein are in situ gelling compositions. The compositions include an anti-inflammatory polysaccharide and a gelling polymer, wherein the composition is a liquid prior to administration to a subject but converts to a gel upon administration to the subject. The compositions described herein have numerous applications with respect to the local treatment (reduction or prevention) of inflammation and/or tissue damage.

In situ gelling compositions for the treatment or prevention of inflammation and tissue damage

The present invention generally relates to deuterium-enriched hyaluronan, d-HA, compositions containing the same, methods of using the same, and methods for making the same. 

Deuterium-enriched hyaluronan

Described herein are pharmaceutical compositions composed of low molecular weight sulfated hyaluronan.

Pharmaceutical compositions composed of low molecular weight sulfated hyaluronan

Described herein is the use of partially and fully sulfated hyaluronan or the pharmaceutically acceptable salt or ester thereof for therapeutic and cosmetic applications as well as the treatment of a number of systemic, dermatological, periodontal, ophthalmic, and urological inflammatory diseases.

Applications of partially and fully sulfated hyaluronan

Described herein are methods for treating inflammation in a subject comprising administering to the subject an effective amount of a modified hyaluronan or a pharmaceutically acceptable salt or ester thereof, wherein said hyaluronan or its pharmaceutically acceptable salt or ester comprises at least one sulfate group and the primary C-6 hydroxyl proton of at least one N-acetyl-glucosamine residue is substituted with a C-Cunsubstituted alkyl group or fluoroalkyl group.

Use of alkylated semi-synthetic glycosaminoglycosan ethers for the treatment of inflammation

Described herein are methods for treating or preventing urological inflammation in a subject comprising administering to the subject an effective amount of a compound comprising a. a modified hyaluronan or a pharmaceutically acceptable salt or ester thereof, wherein said hyaluronan or its pharmaceutically acceptable salt or ester comprises at least one sulfate group and at least one primary C-6 hydroxyl position of an N-acetyl-glucosamine residue comprising an alkyl group or fluoroalkyl group; b. a partially or fully sulfated hyaluronan or the pharmaceutically acceptable salt or ester thereof, or a combination thereof.

Methods for treating or preventing urological inflammation

Described herein are methods for treating a dental disorder in a subject comprising administering to the subject an effective amount of a modified hyaluronan or a pharmaceutically acceptable salt or ester thereof, wherein said hyaluronan or its pharmaceutically acceptable salt or ester comprises at least one sulfate group and the primary C-6 hydroxyl proton of at least one N-acetyl-glucosamine residue is substituted with a C-Cunsubstituted alkyl group or fluoroalkyl group.

Use of alkylated semi-synthetic glycosaminoglycosan ethers for the treatment of dental disorders

Described herein are methods and compositions for killing or preventing the growth of microbes. It has been discovered that a class of porphyrins can kill or prevent the growth of microbes. The porphyrins can be used in a number of different applications where microbes grow.

Compositions for killing or preventing the growth of microbes

Described herein are crosslinked compounds useful in numerous treatments. Described herein are methods of making crosslinked compounds via (1) the oxidative coupling of two or more thiol compounds or (2) by the reaction between at least one thiol compound with at least one thiol-reactive compound.

Crosslinked compounds and methods of making and using thereof

Described herein is the synthesis and pharmacology of a series of &#x3b1;-substituted methylene phosphonate analogs, in which the &#x3b1;-CHmoiety is replaced with CHCl or CHBr.

Alpha-chloro and alpha-bromo phosphonate analogs of lysophosphatidic acid and methods of making and using thereof

Growing community of inventors

Salt Lake City, UT, United States of America

Glenn D Prestwich