University of Manitoba

Emory University

Glen M Lang

Alec Sehon

Judith A Kapp

Yong Ke

A method for specifically suppressing the capacity of a mammal receiving gene therapy to mount an immune response to a given expressed gene of the deficient gene in question, which response is caused by the administration of 'foreign' DNA encoding an antigenic protein or vectors comprising such DNA for expression of the deficient gene in the patient receiving gene therapy.

Method for gene therapy involving suppression of an immune response

A method for suppressing the capacity of a mammal to mount an immune response which would be caused by the administration of one or more biologically active foreign proteins, comprising the administration of an immunosuppressively effective amount of a tolerogen corresponding to the foreign protein or proteins conjugated to mono methoxy (polyethylene glycol), administration being performed prior to the administration of the protein or proteins.

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Winnipeg, Canada

Glen M Lang