Baylor College of Medicine

Vgx Pharmaceuticals, Inc.

Advisys, Inc.

Inovio Pharmaceuticals, Inc.

Glen King

Robert Hunt Carpenter

Ruxandra Draghia-Akli

Robert J Schwartz

Malcolm K Brenner

Douglas R Kern

Kevin Hahn

The present invention pertains to compositions and methods useful for treating anemia and other effects that are commonly associated in cancer bearing animals. The invention is accomplished by delivering an effective amount of a nucleic acid expression construct that encodes a GHRH or functional biological equivalent thereof into a tissue of an animal and allowing expression of the encoded gene in the animal.

Gene therapy expression of GHRH for increasing RBC count in subjects

The present invention pertains to compositions and methods for plasmid-mediated supplementation. The compositions and method are useful for retarding the growth of the tumor, and retarding cachexia, wasting, anemia and other effects that are commonly associated in cancer bearing animals. Overall, the embodiments of the invention can be accomplished by delivering an effective amount of a nucleic acid expression construct that encodes a GHRH or functional biological equivalent thereof into a tissue of an animal and allowing expression of the encoded. gene in the animal. For example, when such a nucleic acid sequence is delivered into the specific cells of the tissue specific constitutive expression is achieved.

Treating anemia in subjects by administration of plasmids encoding growth hormone releasing hormone

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Rosharon, TX, United States of America

Glen King