Mayo Foundation for Medical Education and Research

Arizona State University

The Translational Genomics Research Institute

Scottsdale Healthcare Corporation

Glen J Weiss

Douglas Lake

Thai H Ho

Sara Nasser

Seungchan Kim

The present invention includes a method for screening one or more agents that modulate Regulatory T cell (Treg) activity, the method comprising the steps of: incubating a population CD4+ cells isolated from human blood peripheral mononuclear cells the CD4+ cells in contact with MoT cells in the presence of the one or more agents suspected of modulating Treg activity; detecting activation of the CD4+ cells without or with the agent; and comparing the activation of the CD4+ cells without or with the agent, wherein a change in activation following incubation with the agent relative to the activation of the PBMCs following incubation without the agent indicates that the agent is a modulator of Treg activity.

MoT cells as a therapeutic screening tool for regulatory t-cell activity

Methods and kits that use miRNA expression to predict the development of brain metastases in non-small cell lung cancer patients are disclosed.

Methods of assessing a risk of cancer progression

Growing community of inventors

Phoenix, AZ, United States of America

Glen J Weiss