Molecure S.a.

Gleb Andryianau

Sylwia Olejniczak

Krzysztof Matyszewski

Marzena Mazur

Robert Koralewski

Wojciech J Czestkowski

Agnieszka Bartoszewicz

Adam Gołębiowski

Łukasz Krzemiński

Elżbieta Pluta

Rafał Kozieł

Jacek Olozak

Michał Kowaiski

Michal Czesław Piotrowicz

Barbara Dymek

Katarzyna Krysztofiak

Disclosed are assays for screening active compounds interfering with interaction between chitinase-like protein YKL-40 and chitin oligomers, as well as interfering with interaction between chitinase-like protein YKL-40 and heparan sulfate. Moreover, disclosed are active compounds identified by these assays as inhibitors of chitinase-like protein YKL-40, their therapeutic applications, and their use in biosensors measuring the level of chitinase-like protein YKL-40 in biological samples.

YKL-40 inhibitors and their therapeutic

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Irvine, CA, United States of America

Gleb Andryianau