Trellis Bioscience, Inc.

Tunitas Therapeutics, Inc.

Gizette Sperinde

Lawrence M Kauvar

Orit Foord

Bruce Alan Keyt

Krista Maureen McCutcheon

Fen Zhang

William Usinger

Ellen J Collarini

Ying-Ping Jiang

Minha Park

Bo Chen

Stote Ellsworth

Marjan Fatholahi

Hung Nguyen

Nolan Sigal

Krista Maureen Mccutcheon

Recombinant monoclonal antibodies to human cytomegalovirus (CMV) gB protein are described. The affinities of these antibodies are higher than the best previously reported antibodies. Since high affinity is critical to prevention of virus transfer across the placenta, the invention antibodies are useful as therapeutic and prophylactic agents to prevent or ameliorate effects on the fetus of CMV infection during pregnancy.

High affinity human antibodies to human cytomegalovirus (CMV) gB protein

High affinity human antibodies to human cytomegalovirus (CMV) GB protein

Recombinant materials and methods for producing antibodies that specifically bind heregulin-coupled HER3, at a site distinct from the heregulin binding site, are described. These antibodies are particularly useful in treating cancer that expresses HER3.

Antibodies immunoreactive with heregulin-coupled HER3

Epsi-gam provides a novel fusion protein with the ability to cross-link either of the Fc&#x3b5;RI or Fc&#x3b5;RII cell surface receptors with an Fc&#x3b3;RIIb cell surface receptor in order to block IgE-mediated biological responses.

Epsigam fusion protein

Antibodies to human Cytomegalovirus (CMV) gB protein have been isolated from human B cells. The affinities of these antibodies are higher than the best previously reported antibodies. Since high affinity is critical to prevention of virus transfer across the placenta, the invention antibodies are useful as therapeutic and prophylactic agents to prevent or ameliorate effects on the fetus of CMV infection during pregnancy.

Antibodies which specifically bind heregulin-coupled HER3, at a site distinct from the heregulin binding site, are described. These antibodies are particularly useful in treating cancer.

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El Granada, CA, United States of America

Gizette Sperinde