Apr Applied Pharma Research Sa

Giuseppe Vecchi

Method for optically resolving an enantiomeric mixture of ethodolic acid to produce the S (+) enantiomer is provided wherein the enantiomeric mixture is salified with at least 0.5 moles per mole of a mixture of alpha-(+)-phenethylamine enantiomers in an organic solvent. The resulting precipitate containing the salt of optically active phenethylamine and the S-(+)-enantiomer of the ethodolic acid is separated followed by isolation of the optically enantiomer. Salification of the acid with organic and inorganic bases, selected from basis amino acids, morpholine, aminopyridine and benzylalkyltrimethylammonium derivatives provides new therapeutically effective derivatives.

Method for the preparation of S-(+)-ethodolic acid and saline derivatives

Process for the preparation of the optically active [6(S)(-)]N.sup.5 alkaline earth metal salts of methyltetrahydrofolic acid and formyltetrahydrofolic acid wherein an aqueous solution of folic acid is hydrogenated with a high stoichiometric excess of sodium borohydride followed by treating the reaction product with formic aldehyde and optionally further with sodium borohydride when the methyl derivative is desired. Reaction with a salt of the alkaline earth metal precipitates the desired optically active alkaline earth metal salt.

Process for the preparation of substituted tetrahydrofolico derivatives

The pyrrole derivatives having the general formula: ##STR1## wherein X and X' represent H, alkyl, alkoxy, halogen, nitro, amino, and R is H, alkyl, aryl, arylalkyl, cycloalkylmethyl, are active against pathogenic microorganisms, and particularly against mycetes and Gram-positive and Gram-negative bacteria.

Trisubstituted pyrrole derivatives having antifungine activity, and

Commercial carrageenin is purified to render it suitable for pharmaceutical, dietetic and cosmetic use by treatment with hydrogen peroxide in the presence of a hydrated inert organic solvent.

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Aldesago, Switzerland

Giuseppe Vecchi