Farmitalia Carlo Erba S.p.a.

Farmitalia Carlo Erba S.r.l.

Giuseppe Mazzini

Ettore Lazzari

Piero Melloni

Arturo D Torre

Luigi Bernardi

Marco Alpegiani

Giovanni Franceschi

Ettore Perrone

Franco Zarini

Alessandro Rossi

Lorenzo Pegrassi

Maria L Malnati

Antibacterial penems of formula (I), where R represents a hydrogen atom or a hydroxy protecting group, are prepared by reacting a .beta.-lactam of formula (II) with an oxalyl halide in an inert solvent in the presence of an organic or inorganic base or an acid scavenger to produce a compound of formula (III), wherein X is a halogen atom, treating the resultant compound of formula (III) with a 1,3-dioxolen-2-one of formula (IV), wherein Y is a hydroxy group, in the presence of molecular sieves or an organic or inorganic base to produce a compound of formula (V), and cyclizing the compound of formula (V) in the presence of a trialkylphosphite to provide the penems of formula (I).

Process for penems

The present invention relates to a new process for the preparation of 3-substituted derivatives of 1-amino-2-hydroxy-propane in the form of single diastereoisomers, to certain of these diastereoisomers, and to compounds which are intermediates in the new process of the invention.

Process for the preparation of 3-substituted derivatives of

The present invention relates to a new process for the preparation of 3-substituted derivatives of 1-amino-2- hydroxy-propane in the form of single diastereoisomers, to certain of these diastereoisomers, and to compounds which are intermediates in the new process of the invention.

Process for preparation of 3-substituted derivatives of

There are provided compounds of formula 1: ##STR1## wherein R=halogen atom or CN, NH.sub.2 and NO.sub.2 group, and pharmaceutically acceptable salts thereof. The compounds are antipsycotic agents.

Antipsycotic benzoxazines

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Milan, Italy

Giuseppe Mazzini