Sigma-tau Industrie Farmaceutiche Riunite S.p.a.

Bracco Imaging S.p.a.

Giuseppe Marazzi

Walter Cabri

Luciano Lattuada

Roberta Napolitano

Zsolt Baranyai

Nicole Guidolin

Giuseppe Bianchi

Patrizia Ferrari

Mauro Marzi

Alberto Cerri

Mauro Gobbini

Marco Torri

Fabrizio Giorgi

Silvia Armaroli

Giorgio Fedrizzi

Elena Badaloni

The present invention relates to the RRR/SSS pair of enantiomers of the of Gd(PCTA-tris-glutaric acid), the single enantiomers of the pair, the pharmaceutically acceptable salts thereof, their amide derivatives, and compositions comprising at least 50% of these compounds.

Gadolinium bearing PCTA-based contrast agents

New aminooxime derivatives at position 3 of 2- and/or 4-substituted androstanes and androstenes, processes for their preparation, and to pharmaceutical compositions containing them for the treatment of cardiovascular disorders, such as heart failure and hypertension. In particular compounds having the general formula (I) are described, where the radicals have the meanings described in detail in the application. 

Aminooxime derivatives of 2- and/or 4-substituted androstanes and androstenes as medicaments for cardiovascular disorders

This invention relates to a process for preparing a crystalline form of (4S)-11(dimethoxymethyl)-4-ethyl-4-hydroxy-1H-pyrano[3'4&#x2032;:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, also named 7-(dimethoxy-methyl)camptothecin). With the provision of a particular crystallization step, in appropriate way, a new crystalline form of the above compound is obtained. The process for the preparation of the polymorph Form II comprises transforming camptothecin to the corresponding 7-(dimethoxy-methyl)-camptothecin, and crystallizing from methanol.

Crystalline form II of 7-(dimethoxy-methyl) camptothecin, its use as intermediate and products obtained therefrom

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Milan, Italy

Giuseppe Marazzi