Bracco International Bv

Dibra S.p.a.

Bracco Imaging S.p.a.

Giuseppe Manfredi

Marino Brocchetta

Fulvio Uggeri

Pier Lucio Anelli

Giorgio Ripa

Maria Argese

Franco Fedeli

Fabrizio Rebasti

Luciano Lattuada

Massimo Visigalli

Christoph De Haen

Pierfrancesco Morosini

Giovanna Lux

Ornella Gazzotti

Michele Serleti

Daniela Palano

A process for the preparation of compound of formula (I A), decahydro-2a,4a,6a,8a-tetraazacyclopent[fg]accnaphthylene and the corresponding functionalized compounds of general formula (I), intermediates for the preparation of 1,4,7,10-tetraazacyclododecane (II A) and corresponding derivatives (II), by preparation of compounds of general formula (III) and subsequent reduction thereof.

Process for the preparation of decahydro-2a,4a,6a,8a-tetraazacyclopent[fg]acenaphthylene and functionalized derivatives

1,4,7,10-Tetraazacyclodecane, a precursor for the synthesis of macrocylic chelating agents for metal ions such as gadolinium, is prepared efficiently as a highly pure product on an industrial scale.

Process for the preparation of 1,4,7,10-tetraazacyclododecane

Blood pool imaging contrast agents containing paramagnetic bi- and tri-valent metal ion chelates of bile acid conjugates with molecules having chelating activity are used in magnetic resonance imaging of the vascular system and particularly the coronaries.

Use of bile acid conjugates, derivatives thereof with metal complexes as blood pool agents for nuclear magnetic resonance diagnostics

This invention relates to novel compounds able to chelate paramagnetic bi- or trivalent metal ions, their chelates with said metal ions and their use as contrast agents in magnetic resonance imaging (MRI).

Macrocyclic chelants, their chelates and uses thereof in the diagnostic

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Milan, Italy

Giuseppe Manfredi