Merck Patent Gmbh

Vifor (International) Ag

Ksq Therapeutics, Inc.

Vifor Ag

Giuseppe Lapadula

Fritz Blatter

Rudolf Moser

Viola Groehn

Martin Szelagiewicz

Ruth Boehni Stamm

Markus Ruettimann

Erik Philipp

Stefan Reim

Michael Burgert

Hanlan Liu

Collin D Morris

Jeremy Clinton Wilt

Friedrich Blatter

Crystalline monosodium salt of 5-methyl-(6S)-tetrahydrofolic acid wherein the molar ratio of 5-methyl-(6S)-tetrahydrofolic acid to sodium is from 1:0.5 to 1:1.5 (in mol/mol) and/or hydrates and/or solvates thereof, their use as pharmaceuticals, as well as processes of obtaining the same.

Crystalline monosodium salt of 5-methyl-(6S)-tetrahydrofolic acid

The present disclosure relates to: a) solid state forms of a compound of Formula (I), a compound of Formula (II), and a compound of Formula (III); b) pharmaceutical compositions comprising one or more solid state forms of a compound of Formula (I), a compound of Formula (II), and a compound of Formula (III), and optionally, a pharmaceutically acceptable carrier or diluent; c) methods of treating tumors or cancers by administering one or more solid state forms of a compound of Formula (I), a compound of Formula (II), and a compound of Formula (III) to a subject in need thereof; and d) methods for the preparation of solid state forms of a compound of Formula (I), a compound of Formula (II), and a compound of Formula (III).

Solid state forms of substituted pyrazolopyrimidines and uses thereof

The present invention is directed to a crystalline sodium salt of 5-methyl-(6S)-tetrahydrofolic acid wherein the molar ratio of 5-methyl-(6S)-tetrahydrofolic acid to sodium is from 1:0.5 to 1:1.5 (in mol/mol) and/or hydrates and/or solvates thereof, as well as, a processes of obtaining the same.

The invention relates to novel salts of compounds of the general formula (I), pharmaceutical compositions comprising them and the use thereof as medicaments, in particular for the use as ferroportin inhibitors, more particularly for the use in the prophylaxis and/or treatment of diseases caused by a lack of hepcidin or iron metabolism disorders, such as particularly iron overload states such as in particular thalassemia, sickle cell disease and hemochromatosis.

Ferroportin-inhibitor salts

The present invention is directed to crystalline salt of 5-methyl-(6S)-tetrahydrofolic acid comprising

Crystalline binary sodium salts of 5-methyl-(6S)-tetrahydrofolic acid with organic bases

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Basel, Switzerland

Giuseppe Lapadula