Dr. Lo. Zambeletti S.p.a.

Other

Dr. Lo. Zambelletti Spa

Glaxosmithkline LLC

Lo Zambeletti S.p.a.

Dr. Lo Zembeletti S.p.a.

Giuseppe Giardina

Vittorio Vecchietti

Roberto Colle

Mario Grugni

Carlo Farina

Luca Francesco Raveglia

Giulio Dondio

Silvano Ronzoni

Giorgio Cignarella

Guy Marguerite Marie Gerard Nadler

Daniela Barlocco

Guy Marguerite Marie G&eacute;rard Nadler

Marcel Morvan

Robert Colle

Lorenzo Leurini

Compounds of formula (I) or a derivative thereof, wherein; R is Calkyl, Ccycloalkyl, Calkoxy, hydroxy, halo, Calkenyl, Calkynyl, amino, Calkylamino, di(Calkyl)amino, hydroxyCalkyl, CalkoxyCalkyl, aminoCalkyl, (Calkyl)aminoCalkyl, di(Calkyl)aminoCalkyl; Ris hydrogen or R; Ris hydroxy, Calkoxy, amino, Calkylamino, di(Calkyl)amino; Ris hydrogen or Calkyl; Rand Rare each independently selected from the list consisting of perhaloCalkyl, hydrogen, halo, Calkyl, Calkoxy, hydroxy, amino, Calkylamino, di(Calkyl)amino, hydroxyCalkyl, CalkoxyCalkyl, aminoCalkyl, (Calkyl)aminoCalkyl, di(Calkyl)aminoCalkyl, aryl, and COX wherein X may be hydroxy, Calkoxy, Calkyl, amino, Calkylamino, or di(Calkyl)amino; with the proviso that, when Ris hydrogen, then Rand Rare not both hydrogen; and wherein any alkyl group or the alkyl moiety of any group containing such a moiety may be substituted one or more times by halo; are ligands of the ORL-1 receptor and are useful in therapy. 

Benzosuberonylpiperdine compounds as analgesics

Quinoline-4-carboxamide derivatives as NK-3 and NK-2 receptor antagonists

Quinoline derivatives as NK-2 and NK-3 receptor ligands

##STR1## Azacyclic derivatives of formula (I), in which R.sub.1 and R.sub.2 are each linear or branched alkyl, cycloalkyl, cycloalkylalkyl, alkenyl, cycloalkenyl or alkynyl; R.sub.3 and R.sub.4 are identical, and each is a hydrogen or alkyl; and R.sub.5 is hydrogen or alkyl, and their use in medicine are disclosed.

1-(2H-1-oxo-3,4-dihydronaphtyl-6-yl)-acetyl-piperidines as kappa agonists

N-acyl-substituted azacyclic compounds, processes for their preparaion,

N-acyl-substituted azacyclic compounds, processes for their preparation,

A compound, or a solvate or salt thereof, of formula (I): ##STR1## in which: RCO is an acyl group in which the group R contains a substituted or unsubstituted carbocyclic aromatic or heterocyclic aromatic ring and R.sub.1 and R.sub.2 are independently hydrogen, C.sub.1-6 alkyl, C.sub.2-6 alkenyl, C.sub.3-6 cycloalkyl or C.sub.4-12 cycloalkylalkyl groups or together form a C.sub.2-8 branched or linear polymethylene or C.sub.2-6 alkenylene group optionally substituted with a hetero-atom;

Substituted isoquinoline compounds, pharmaceutical composition and

A compound, or a solvate or salt thereof, of formula (I): ##STR1## in which R represents a group of formula (II) ##STR2## in which R.sub.x is the remainder of a heterocyclic group, or an optionally substituted phenyl group;

Tetrahydroisoquinoline and tetrahydrothieno derivatives

A compound of formula (I): ##STR1## or a salt and/or solvate thereof, wherein R represents an acyl group containing a substituted or unsubstituted carbocyclic aromatic or heterocyclic aromatic group;

2-aminoethylamine derivatives, compositions of the same and use of said

A compound, or a solvate or salt thereof, of formula I: ##STR1## in which: R.CO-- is an acyl group containing a substituted or unsubstituted carbocyclic aromatic or heterocyclic aromatic group;

Heterocyclic ethylene diamine compounds and their pharmaceutical

A compound, or a solvate or salt thereof, of formula (I): ##STR1## in which: RCO is an acyl group in which the group R contains a substituted or unsubstituted carbocyclic aromatic or heterocyclic aromatic ring and R.sub.1 R.sub.2 are independently hydrogen, C.sub.1-6 alkyl, C.sub.2-6 alkenyl, C.sub.3-6 cycloalkyl or C.sub.4 -12 cycloalkylalkyl groups or together form a C.sub.2-8 branched or linear polymethylene or C.sub.2-6 alkenylene group optionally substituted with a hetero-atom;

Isoquinoline derivatives and their use as analgesics

A compound of formula 1, or a solvate or salt thereof: ##STR1## in which: RCO is an acyl group in which the group R comprises a substituted or unsubstituted carbocyclic or heterocyclic aromatic ring and R.sub.1 and R.sub.2 are independently C.sub.1-6 alkyl groups or together form a C.sub.3-6 polymethylene or alkenylene group, is useful for treating pain.

Isoquinoline derivatives, analgesic compounds thereof and method of

Growing community of inventors

Milan, Italy

Giuseppe Giardina