Spa Societa Prodotti Antibiotici S.p.a.

Caffaro S.p.a.

Caffaro, S.p.a., Societa Per L'industria Chimica Ed Elettrochimica

Societa Prodotti Antibiotici S.p.a.

Giuseppe Ghielmetti

Tiberio Bruzzese

Liborio Casale

Rodolfo Ferrari

Enrico Pontoglio

Giordano Donelli

Sandro Parodi

Franco Ottoni

The present invention is directed towards a series of secondary and tertiary amide derivatives of Partricin A & Partricin B attached at the C-18 carboxyl group. The compounds can be used in the treatment of hypercholesteremia and hyperlipemia conditions, of steroidal imbalances, and as antifungal and antiprotozoan agents.

Amide derivatives of Partricin A & Partricin B

The invention relates to a process for the preparation of tetrachloroterephthaloyl dichloride by means of the chlorination of terephthaloyl dichloride with gaseous chlorine, characterized in that said chlorination is carried out in the vapor phase in the presence of activated charcoal as catalyst. The invention relates also to the synthesis processes in which the compound prepared according to the process said is used as an intermediate.

Process for the preparation of tetrachloroterephthaloyl dichloride by

In an improved process for the continuous production of tetrachlorophthalonitrile, of the type with activated carbon fluidized bed reactor, under whose grid melted and atomized phthalonitrile, chlorine, hydrochloric acid and possibly nitrogen are simultaneously introduced the use of a second static bed reactor, also of activated carbon, in series with the first, is provided for, thereby greatly improving the life of the catalyzer, and, above all, the quality of the product.

Process for the continuous production of tetrachlorophthalo-nitrile in

The present invention provides new esters of partricin and of N-substituted derivatives of partricin.

Esters of partricin derivatives

There are described preparations containing glucides and non-toxic, physiologically compatible salts of phosphorylated glucides which can be administered orally or parenterally.

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Milan, Italy

Giuseppe Ghielmetti