Universitá Degli Studi Di Padova

Dipartimento Di Ingegneria Civile E Architettura Dell'università Degli Studi Di Pavia

Giuseppe De Nicolao

Claudio Cobelli

Andrea Facchinetti

Giovanni Sparacino

Chiara Dalla Man

Stefania Guerra

Chiara Toffanin

Paola Soru

Lalo Magni

In a method of recalibrating continuous glucose monitoring data from a user, operable on a digital processor, an indication from the user that the user has taken a meal is received (). A self-monitored of blood glucose levels from the user () at two separate times during a day corresponding to when the user has taken a meal. A glucose signal is received from a continuous glucose monitoring sensor () at times corresponding to the two separate times that the user has taken a meal. Two reconstructed blood glucose values based on the glucose signal from the continuous monitoring sensor at times when the at least two self-monitored of blood glucose levels are received from the user. A linear regression is performed () using y=ax+b, wherein x corresponds to the two reconstructed blood glucose values and y corresponds to the two self-monitored of blood glucose levels thereby generating an estimation of a and b. A recalibration signal, including the estimation of a and b, is transmitted to the continuous glucose monitoring sensor () based on the linear regression.

Method to recalibrate continuous glucose monitoring data on-line

A method () controls the delivery of insulin in a diabetic patient (P) based on data (d) representative of at least a fraction of a meal (m(k+i)) that the patient (P) will consume. The method provides from a block (R) representative of conventional therapy or open loop rule that the patient (P) is subject to, based on the data (d) representative of at least a fraction of the meal (m(k+i)), a reference insulin value (u). The method is also based on data representative of the difference between input data (&#x177;), a reference glycemic level, and feedback data (y) representative of the glycemic level detected in the patient (P). A control module () provides a value of insulin (i) to be delivered to the patient (P) based on the various representative data.

Method for controlling the delivery of insulin and the related system

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Milan, Italy

Giuseppe De Nicolao