Universita′ Degli Studi Di Milano

Epitech Group S.r.l.

Ieo - Istituto Europeo Di Oncologia S.r.l.

I.r.c.c.s. “Casa Sollievo Della Sofferenza”

Giuseppe D'Agostino

Francesco Della Valle

Maria Federica Della Valle

Gabriele Marcolongo

Roberto Russo

Pierre-Luc Germain

Antonio Calignano

Sonia Laneri

Rosaria Meli

Sina Atashpazgargari

Giuseppe Merla

Carmine Ostacolo

Matteo Zanella

Antonia Sacchi

Giuseppe Testa

Antonio Adamo

Diana Tronino

The present invention relates to iPSC produced from fibroblast obtained from a subject affected by a neurodevelopmental disorder entailing intellectual disability (ID) and/or a disorder belonging to the Autism Spectrum Disorder (ASD) and/or Schizophrenia (SZ) and uses thereof. The present invention also relates to a cortical neural progenitor cell or a terminally differentiated cortical glutamatergic or gabaergic neuronal cell or a neural crest stem cell line, a mesenchymal stem cell line produced from the iPSC or iPSC line. The invention also relates to method for identifying a compound for the treatment and/or prevention of a neurodevelopmental disorder entailing intellectual disability (ID) and/or a disorder belonging to the Autism Spectrum Disorder (ASD) and/or Schizophrenia (SZ) and to a LSD1 inhibitor or a HDAC2 inhibitor for use in the treatment of such disorders.

Reprogramming-based models of neurodevelopmental disorders and uses thereof

The synthesis of a series of Polyethylene glycol conjugates (esters and carbonates) of PEA and its analogous acylethanolamides, have higher water solubility and good hydrophilic/lipophilic balance, resulting in (i) improved accumulation in tissues (particularly skin and mucosae), (ii) prolonged release, and (iii) increased bioavailability. Improvement of PEA and analogous acylethanolamides levels in the tissues&#x2014;particularly in the skin and mucosae&#x2014;and their prolonged release is due to the improved bioavailability of related conjugates. Conjugates are able to extend the time frame in which PEA and analogous acylethanolamides exert their pharmacological effects.

Polyethylene glycol derivatives of palmitoylethanolamide and analogous acylethanolamides

Growing community of inventors

Milan, Italy

Giuseppe D'Agostino