Istituto De Angeli S.p.a.

Boehringer Ingelheim Italia S.p.a.

Giuseppe Bietti

Enzo Cereda

Arturo Donetti

Antonio Giachetti

Piero Del Soldato

Ferdinando Pagani

Rosamaria Micheletti

Marco Turconi

Giovanni Battista Schiavi

Maura Bignotti

Ettore Giraldo

Henri N Doods

Antonio Schiavone

Franco Borsini

Pharmacologically active benzimidazolone derivatives as 5-HT.sub.1A and 5-HT.sub.2 receptors, useful in the treatment of CNS disorders, of formula: ##STR1## wherein the substituents are defined herein.

Benzimidazolone derivatives

Pharmacologically active R(-) 3-quinuclidinol derivatives are described which are muscarinic receptor blocking agents useful for the treatment of gastrointestinal and respiratory tract disorders of the following formula (I) ##STR1## wherein R represents a linear or branched lower alkyl group, a cycloalkyl-C.sub.1-2 alkyl or an aralkyl group, or it is absent;

R(-)3-quinuclidinol derivatives

Compounds of the formula ##STR1## wherein R is hydrogen or methyl;

Substituted heterocyclyl-phenylformamidines and salts thereof

Formamidine derivatives and pharmaceutical use

Compounds of the formula ##STR1## wherein R represents substituents of various types;

Antiulcerogenic amidine derivatives of 2-substituted 4-phenylimidazole

Compounds of the tautomeric formula ##STR1## wherein R, R.sub.1 and R.sub.2, which may be identical to or different from each other, are each hydrogen or alkyl of 1 to 4 carbon atoms; R.sub.3 is straight or branched alkyl, optionally interrupted by heteroatoms such as oxygen, sulfur or nitrogen; straight or branched alkenyl; alkynyl; cyano; cycloalkyl or cycloaliphatic alkyl; a bicyclic group; aryl; or a heterocyclic group; or R.sub.2 and R.sub.3, together with each other and the nitrogen atoms to which they are attached, form a heterocyclic group; R.sub.4 is hydrogen, halogen, alkyl of 1 to 4 carbon atoms or alkoxy of 1 to 4 carbon atoms; and Het is a substituted or unsubstituted heterocycle containing two or three heteroatoms; tautomers thereof, and non-toxic, pharmacologically acceptable acid addition salts thereof. The compounds as well as their salts are useful as anti-ulcerogenics.

Guanidino-heterocyclyl-phenyl-amidines and salts thereof

Compounds of the tautomeric formula ##STR1## wherein R, R.sub.1 and R.sub.2, which may be identical to or different from each other, are each hydrogen or alkyl of 1 to 4 carbon atoms;

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Milan, Italy

Giuseppe Bietti