Secifarma S.p.a.

Secrifarma S.p.a.

Giuseppe Bernini

An improved process for the resolution of (+)-6-methoxy-.alpha.-methyl-2-naphthaleneacetic acid into the corresponding enantiomers by using L-threo-(+)-2-amino-1-(4-nitrophenyl)-1,3-propanediol and L-threo-(+)-2-amino-1-(4-methylmercaptophenyl)-1,3-propanediol.

Process for the resolution of

The invention relates to a process for the resolution of mixtures of D and L-6-methoxy-alpha-methyl-2-naphthaleneacetic acid in their respective antipodes. L-threo(+)-2-amino-1-p-nitrophenyl-1,3-propandiol is proposed as new resolving agent.

Process for the enantiomeric resolution of mixtures of D and

The invention relates to a process for preparing a spironolactone, having increased biological activity, by precipitation with water from a solution with preferably organic solvents at a temperature between 0.degree. and 30.degree. C. and under vigorous stirring.

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Milan, Italy

Giuseppe Bernini