Merck Sharp + Dohme Corp.

Acs Dobfar S.p.a.

Calixa Therapeutics, Inc.

Giuseppe Alessandro Donadelli

Giovanni Fogliato

Joseph Terracciano

Nicole Miller Damour

Chun Jiang

Dario Resemini

Maurizio Zenoni

Mario Leone

Pharmaceutical compositions are provided in unit dosage forms comprising ceftolozane and tazobactam in separate unit dosage form containers, ceftolozane prepared in the absence of tazobactam, tazobactam prepared in the absence of ceftolozane, and/or compositions where ceftolozane and tazobactam are first combined within a unit dosage form container.

Ceftolozane-tazobactam pharmaceutical compositions

This disclosure provides pharmaceutical compositions comprising ceftolozane, pharmaceutical compositions comprising ceftolozane and tazobactam, methods of preparing those compositions, and related methods and uses of these compositions.

Ceftolozane antibiotic compositions

Pharmaceutical compositions can include ceftolozane lyophilized in the absence of tazobactam.

Process for selectively reducing cephalosporin sulfoxides of 3-hydroxy cephem and 3-methylene cepham compounds by treatment with a chlorinating agent in the presence of a solvent and a base, which are both inert to the chlorinating agent.

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Casalpusterlengo, Italy

Giuseppe Alessandro Donadelli