Glaxosmithkline Biologicals Sa

Novartis Vaccines & Diagnostics, Gmbh

Novartis Vaccines and Diagnostics Srl

Novartis Ag

J. Craig Venter Institute

Chiron S.r.l.

Other

Sclavo Spa

Chiron S.p.a.

Scalvo Spa

Biocine S.p.a.

Giulio Ratti

Guido Grandi

Rino Rappuoli

Mariagrazia Pizza

Vega Masignani

Maria Scarselli

Claire M Fraser

Cesira Galeotti

Herve Tettelin

Marirosa Mora

Vincenzo Scarlato

Erin Hickey

J Craig Venter

Jeremy Petersen

Marzia Monica Giuliani

Mario F Tecce

Maurizio Comanducci

Stefano Ricci

Mariarosa Mora

Benedetto Terrana

Jeremy D Peterson

Craig Ventor

Hervé Tettelin

Mariagratia Pizza

Enzo Scalato

The invention provides proteins from, including the amino acid sequences and the corresponding nucleotide sequences. The proteins are predicted to be useful antigens for vaccines and/or diagnostics.

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The invention is in the field of immunology and vaccinology. In particular, it relates to antigens derived fromthat are expressed on the cell surface and so are ideal for use in immunization as well as combinations of these antigens.

Chlamydial antigens

The present invention provides variant LcrE sequences and/or combinations of variant LcrE sequences across theserovars. Such changes in LcrE genotypes across theserovars are likely to correspond with changes in LcrE phenotypes, in particular, with changes in immunogenicity. The present invention also provides peptides surrounding or associated with the amino acid substitutions, in particular, peptides surrounding or associated with high frequency mutated amino acid positions or hypervariable regions, which are likely to be B and/or T cell epitopic regions capable of elicitingspecific cell mediated immune responses. The variant LcrE sequences and/or combinations of the variant LcrE sequences and/or epitope regions associated with the variant LcrE sequences are useful as immunogens and/or in the preparation of immunogenic compositions for preventing and/or treating and/or, diagnosinginfections.

Proteins encoded bywhich are immunogenic in humans as a consequence of infection have been identified using Western blots of two-dimensional electrophoretic maps. Several known immunogens were identified, as were proteins not previously known to be immunogens, and proteins not previously reported as expressed gene products.

The present invention provides antigenic proteins of. The proteins of the present invention are useful for eliciting an immune response toin a patient. For example, an effective amount of protein of the present invention or fraction thereof may be administered to a patient for eliciting aspecific immune response. In another example, a method of raising an antibody specific forelementary bodies (EB) is provided in which a protein of the present invention is administered to a patient.

Immunisation against chlamydia trachomatis

The invention provides methods of obtaining immunogenic proteins from genomic sequences including, including the amino acid sequences and the corresponding nucleotide sequences, as well as the genomic sequence of. The proteins so obtained are useful antigens for vaccines, immunogenic compositions, and/or diagnostics.

Uses of the plasmid-encoded protein pgp3 fromserotype D, purified by ion exchange column chromatography and shown to be suitable for quantitative immunoassay on clinical samples in an ELISA format, in methods of eliciting and diagnosing an immune response are described.

A new recombinant form of the plasmid-encoded protein pgp3 from, serotype D, was purified by ion exchange column chromatography and shown to be suitable for quantitative immunoassy on clinical samples in an ELISA format.

A new recombinant form of the plasmid-encoded protein pgp3 from , serotype D, to be used in immunogenic compositions and in the preparation of immunogenic compositions was purified by ion exchange column chromatography and shown to be suitable for quantitative immunoassy on clinical samples in an ELISA format.

Recombinant Chlamydia trachomatis PGP3 antigen

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Siena, Italy

Giulio Ratti