L. Molteni & C. Dei Fratelli Alitti—società Di Esercizio S.p.a.

Cytopharm, Inc.

Frontier Scientific, Inc.

Molteni Therapeutics S.r.l.

L. Molteni & C. Dei Fratelli Alitti

L. Molteni & C. Dei Fratelli

Dpc D.o.o.

Molteni L. & C. Dei Fratelli Alitti Societa Di Esercizio S.p.a.

Giulio Jori

Gabrio Roncucci

Donata Dei

Lia Fantetti

Giacomo Chiti

Maria Paola De Filippis

Moira Municchi

Daniele Nistri

Jerry Charles Bommer

Gian Maria Rossolini

Francesca Giuntini

Francesco Giuliani

Alexander Holtz

Ilaria Masini

Barbara Cosimelli

Yann Raoul

Clara Fabris

Moshe Schaffer

Michelangelo Marullo

The present invention relates to pharmaceutical compositions comprising metal phthalocyanine analogues of formula (I) and metal chelating compounds having a good bioavailability and enhanced photoinactivation properties against Gram negative bacteria; and to their use for in vivolex vivo applications, such as blood and blood derivatives sterilization. 

Antibacterial compositions comprising metal phthalocyanine analogues

The present invention relates to metal-phthalocyanines bearing at least a group containing boron isotopesB orB, covalently bound to the axial positions of metal-phthalocyanine nucleus; moreover it refers to the process for their preparation, the pharmaceutical compositions comprising them and their use for the treatment of neoplastic and dysplastic pathologies in PDT and/or BNCT.

Boronated metal-phthalocyanines, process for their preparation, pharmaceutical compositions comprising them and use thereof

The present invention relates to meta 1-phthalocyanines bearing at least a group containing boron isotopesB orB, covalently bound to the peripheral positions of meta 1-phthalocyanine nucleus; moreover it refers to the processes for their preparation, the pharmaceutical compositions comprising them and their use for the treatment of neoplastic and dysplastic pathologies.

The present invention is directed to metal-phthalocyanines of general formula (I) to the corresponding conjugates, the processes for their preparation and use in the photodynamic therapy of microbial infections (viral, bacterial and mycotic), tumor, pre-cancerous and proliferative pathologies and/or in the diagnosis, as well as for blood and blood derivatives sterilization.

Substituted metal-phthalocyanines, their preparation and the use thereof

The present invention is directed to metal-phthalocyanines of general formula (I) to the corresponding conjugates, the processes for their preparation and use in the photodynamic therapy of microbial infections (viral, bacterial and mycotic), tumor, pre-cancerous and proliferative pathologies and/or in the diagnosis, as well as for blood and blood derivatives sterilization

The invention relates to the utilization of photosensitizers for controlling algae and bacteria in aquaria, whereby compounds of the tetrapyrrol and tetraazopyrrol families having at least one positive charge are used as sensitizers.

Utilization of porphyrin derivatives in aquaria

A series of novel positively-charged porphyrins is disclosed which exhibit a markedly increased efficiency in photosensitizing both Gram-positive and Gram-negative bacteria to the action of visible light, causing death to such bacteria when present at much lower concentrations and much shorter irradiation times than those porphyrins taught in the prior art. These porphyrins are characterized by the presence of up to four positive charges in the peripheral substituents and at least one hydrophobic tail comprising between 6 and 22 carbons inclusive, originating at one or more of the charged sites.

Photodynamic porphyrin antimicrobial agents

Cationic porphycenes are conjugated, through a carboxylic-acid bearing moiety, with polylysine through an amide linkage. The novel porphycenes are effective in treating microbial populations in vitro or in vivo and topically as well as for sterilizing articles.

Porphycenes for treatment of microbial populations

The present invention refers to zinc-phthalocyanines of general formula (I) ##STR1## to processes for their preparation and to their use as phototherapeutic and photodiagnostic agents as free molecules and as conjugates with macromolecular carrier molecules.

Growing community of inventors

Padua, Italy

Giulio Jori