Smithkline Beecham Corporation

Smithkline Beecham Farmaceutici S.p.a

Dr. Lo. Zambeletti S.p.a.

Dr. L. Zambeletti Spa

Dr. Lo Zembeletti S.p.a.

Giulio Dondio

Silvano Ronzoni

Vittorio Vecchietti

Roberto Colle

Giuseppe Giardina

Antonio Giordani

Davide Graziani

Robert Colle

Lorenzo Leurini

Pier Andrea Gatti

Heterocycle-condensed morphinoid derivatives (II)

Compounds, or solvates or salts thereof, of formula (I):

Diarylalkenylamine derivatives

Heterocycle-condensed morphinoid derivatives

Substituted hydroisoquinoline derivatives and their use as

Diaryldiamine derivatives and their use as delta opiod (ANT)-agonists

Octahydro-1H-pyrrolo�3,2-g!and �2,3-g!isoquinoline derivatives

##STR1## Compounds of formula (I) in which, R is linear or branched alkyl, cycloalkyl, cycloalkylalkyl, alkenyl, aryl, aralkyl or furan-2-yl alkyl; R.sub.1 and R.sub.2, which may be the same or different, are each hydrogen, hydroxy, alkoxy, or halogen; R.sub.3 is hydrogen, hydroxy or alkoxy; 'Het' is optionally substituted single or fused heteroxyclic ring, containing from 5 to 10 ring atoms and comprising up to four heteratoms in the or each ring, selected from oxygen, nitrogen and sulphur; R.sub.4 and R.sub.5, which may be the same or different, are each hydrogen alkyl, halogen, nitro; CF, cyano, alkoxy carbonyl, NH, alkylcarbonylamino, hydroxy, alkoxy, or benzyl, are selective delta receptor agonists and are useful in the treatment of pain.

Hydroisoquinoline derivatives

N-acyl-substituted azacyclic compounds, processes for their preparaion,

N-acyl-substituted azacyclic compounds, processes for their preparation,

A compound, or a solvate or salt thereof, of formula (I): ##STR1## in which: RCO is an acyl group in which the group R contains a substituted or unsubstituted carbocyclic aromatic or heterocyclic aromatic ring;

Heterocyclic piperidinyl compounds having analgesic effect

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Milan, Italy

Giulio Dondio