Sigma-Tau Industrie Farmaceutiche Riunite S.p.a.

Giulio Carzana

Giuseppe Bianchi

Patrizia Ferrari

Alberto Cerri

Simona Sputore

Maria Pia Zappavigna

Leonardo Banfi

Mauro Gobbini

Mara Ferrandi

Marco Torri

Rosamaria Micheletti

Silvia Armaroli

Rosamaria Michaeletti

Barbara Moro

Maco Torri

Giuseppe Giacalone

Compounds of formula (I) wherein: the groups are as defined in the description, are useful for the preparation of medicaments for the treatment of cardiovascular disorders, in particular heart failure and hypertension. The compounds are inhibitors of the enzymatic activity of the Na, K-ATPase. Said compounds are used for the preparation of a medicament for the treatment of a disease caused by the hypertensive effects of endogenous ouabain, such as renal failure progression in autosomal dominant polycystic renal disease (ADPKD), preeclamptic hypertension and proteinuria and renal failure progression in patients with adducin polymorphisms. 

Amino derivatives of androstanes and androstenes as medicaments for cardiovascular disorders

New aminoalkoxyimino derivatives at position 3 of substituted B-homoandrostanes and B-heteroandrostanes, processes for their preparation, and to pharmaceutical compositions containing them for the treatment of cardiovascular disorders, such as heart failure and hypertension. In particular compounds having the general formula (I) are described, where the radicals have the meanings described in detail in the application.

Amino derivatives of beta-homoandrostanes and beta-heteroandrostanes

An improved process is described for the preparation of compounds with general formula (I) and particularly for the preparation of the compound (E,Z) 3-(2-aminoethoxyimino)-androstane-6,17-dione, in which n&equals;1 and R &equals;R &equals;H

Process for the preparation of (E,Z) 3-(2-aminoethoxyimino)-androstane-6, 17-dione and its analogues

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Milan, Italy

Giulio Carzana