Farmitalia Carlo Erba S.p.a.

Carlo Erba S.p.a.

Consiglio Nazionale Delle Ricerche

Giuliano Nannini

Ettore Perrone

Giuseppe Meinardi

Carlo Confalonieri

Gisella Monti

Alberta Bianchi

Dino Severino

Angelo Forgione

Marco Alpegiani

Enrico Di Salle

Gianfranco Cainelli

Mauro Panunzio

Giorgio Martelli

Franco Giudici

Ferruccio Casabuona

Silvio Grasso

Giuseppe Spunta

The present invention relates to new 4-aza-17.beta.-substituted 5.alpha.-androstan-3-ones, to a process for their preparation, to pharmacological compostions containing them, and to the use of said compounds as inhibitors of androgen action by means of testosterone 5-reductase inhibition.

Steroidic 5.alpha.-reductase inhibitors

Heteromonocyclic and heterobicyclic derivatives of unsaturated 7-ayclamide-3-cephem-4-carboxylic acid are disclosed, and process for preparing same. These compounds are suitable for treating infections caused by Gram-positive and Gram-negative microorganisms.

Heteromonocyclic and heterobicyclic derivatives of unsaturated

Derivatives of N-substituted thiazolyl oxy-imino-substituted cephalosporins, such as, for instance, the compound 7.beta.-[2-(2-imino-3-hydroxy-4-thiazolinyl)-2-methoxy-imino-acetamino]-3- [(tetrazolo[1,5-b]pyridazin-6-yl)-thiomethyl]-3-cephem-4-carboxylic acid, are disclosed. The disclosed compounds have high anti-bacterial activity against Gram-positive and Gram-negative bacteria normally susceptible to cephalosporins.

N-substituted thiazolyl derivatives of oxy-imino-substituted

Heterocyclyl derivatives of oxy-imino-substituted cephalosporins are disclosed, such, for instance the compound 3-[(8-amino-6-tetrazolo[1,5-b]pyridazinyl)-thiomethyl]-7-[2-(2-amino-4-thi azolyl)-2-methoxyimino-acetamido]-3-cephem-4-carboxylic acid and its pharmaceutically and veterinarily acceptable salts. The compounds of the application have high antibacterial activity against Gram-positive and Gram-negative bacteria, including strong beta-lactamase producer Gram-negative microorganisms.

3-[(8-Carboxy-6-tetraz

Heteromonocyclic and heterobicyclic derivatives of unsaturated 7-acylamido-3-cephem-4-carboxylic acid are disclosed which exhibit antibacterial activity against Gram-positive and Gram-negative microorganisms and can be used to treat infections caused by such microorganisms.

Unsaturated derivatives of 7-acylamido-3-cephem-4-carboxylic acid are disclosed which exhibit antibacterial activity against Gram-positive and Gram-negative microorganisms and can be used to treat infections caused by such microorganisms.

Unsaturated derivatives of 7-acylamido-3-cephem-4-carboxylic acid

Growing community of inventors

Bresso, Italy

Giuliano Nannini