Giuliani S.p.a.

Gipharmex S.p.a.

Giuliano Frigerio

Aldo Roda

Roberto Pellicciari

Danila Ingrid Marchioretto

Enzo Giorgetti

Nicoletta Crespi Perellino

Anacleto Minghetti

Valter Gatti

Bruno Danieli

Paola Messi

Moreno Bondi

Enrico Roda

Virginio Castagnola, Deceased

Giangermano Giuliani

Emilia Chiodini

Compounds with an antioxidant activity, compositions useful as food integrators containing them and process for their preparation

The subject of the present invention is a composition suitable as food integrator and for the treatment of intestinal disorders and alterations of the bacterial flora, characterized in that it contains as active principle a combination of and lysine. A further subject of the present invention is a method for the growth and development of cultures of in the presence of lysine, as well as the use of these bacterial cultures thus produced and developed in the preparation of compositions suitable both as food integrators and as pharmaceutical compositions.

Composition suitable as food integrator and for the treatment of intestinal disorders and alterations of the bacterial flora

The invention provides a pharmaceutical composition for the rectal administration of active principles which exhibit a prevalently topical medication action at the colon level, characterized in that said active principles are formulated in a fluid vehicle able to generate a foam on rectal administration.

Pharmaceutical composition for rectal administration of active

Compounds of formula I: ##STR1## in which the various R groups have the meanings defined in the disclosure are useful as medicaments for the treatment of hepatobiliary diseases.

Bile acid sulfurated derivatives

Compounds of general formula I ##STR1## wherein R.sub.1 is hydrogen or hydroxy, and the hydroxy group at the 7-position can be either in .alpha. or .beta. configuration, are valuable in human therapy. Compounds I can be prepared by fluorination of the suitably protected 6.alpha.-hydroxy-7-keto-derivatives.

Fluorinated bile acid derivatives, processes for the preparation thereof

Compounds of general formula I ##STR1## wherein R.sub.1 is hydrogen or hydroxy, and the hydroxy group at the 7-position can be either in .alpha. or .beta. configuration, are valuable in human therapy. Compounds I can be prepared by reacting with succinic acid carboanions the corresponding derivatives which have previously been protected, and subsequently deprotecting and decarboxylating them.

Bile acid derivatives, processes for the preparation thereof and

The invention provides an orally administered pharmaceutical composition for use in gastrointestinal washes, particularly for diagnostic use, or as a cathartic laxative, of the type containing polyethyleneglycol, anhydrous sodium sulphate, sodium bicarbonate, sodium chloride and potassium chloride, characterized by also containing the following components: saccharin, acesulfame-K and a flavoring chosen from the following: mandarin, fresh fruit flavoring.

Orally administered pharmaceutical composition for use in

A compounds of general formula I ##STR1## wherein R.sub.1 is hydrogen or hydroxy, and the hydroxy group at the 7-position can be either in .alpha. or .beta. configuration, are valuable in human therapy. Compounds I can be prepared by fluorination of the suitably protected 6-hydroxy-7-keto-derivatives.

Compounds of general formula I ##STR1## wherein R.sub.1 is hydrogen or hydroxy, and the hydroxy group at the 7-position can be either in .alpha. or .beta. configuration, are valuable in human therapy. Compounds I can be prepared by reacting with succinic acid carbonanions the corresponding derivatives which have previously been protected, and subsequently deprotecting and decarboxylating them.

The present invention relates to a complex of products useful for the not-invasive and rapid treatment of the biliary calculosis of cholesterolic nature. It is based upon the coupling of a special apparatus generating medium-energy or medium-low-energy ultrasounds with pharmaceutical compositions based on biliary acids, capable of de-saturating bile super-saturated with cholesterol.

Complex of products for the rapid and not-invasive treatment of biliary

Compounds of formula I ##STR1## wherein: R.sub.1 is hydrogen or hydroxy, and the methyl and hydroxy groups at 6- and 7-positions respectively can be either in .alpha. or .beta. configuration, are useful in human therapy. Compounds I are prepared by methylation of the corresponding appropriately protected 7-keto-derivatives.

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Milan, Italy

Giuliano Frigerio