Amgen Inc.

Giulia Lattanzi

Ning Chen

Jennifer Rebecca Allen

Qingyian Liu

Albert Kudzovi Amegadzie

Ana Elena Minatti

Aaron C Siegmund

Jonathan Dante Low

Vu Van Ma

Matthew Paul Bourbeau

Clifford Goodman

Corey Reeves

Alfonso Pozzan

Iain Lingard

Mary Catherine Walton Cabrera

Federica Tonelli

Sabrina Tassini

The present disclosure provides compounds useful for the inhibition of Delta-5 Desaturase (“D5D”). The compounds have a general Formula 1: wherein the variables of Formula I are defined herein. This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, a metabolic or cardiovascular disorder. Further, the disclosure provides intermediates useful in the synthesis of compounds of Formula I.

Heterocyclic compounds as delta-5 desaturase inhibitors and methods of use

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Verona, Italy

Giulia Lattanzi