Veracyte, Inc.

Affymetrix, Inc.

Novartis Vaccines & Diagnostics, Gmbh

Chiron Corporation

Nuvelo, Inc.

Giulia C Kennedy

Darya Chudova

Jonathan I Wilde

Eric T Wang

Moraima Pagan

Hui Wang

Bonnie H Anderson

Nusrat Rabbee

Rui Mei

Christoph Reinhard

Hajime Matsuzaki

Xing Su

Jaime A Escobedo

Filippo M Randazzo

Pablo Dominguez Garcia

George Lamson

Julie Sudduth-Klinger

Sean Walsh

Joerg Kaufmann

Vivien W Chan

Yoonha Choi

Jing Huang

Radoje Drmanac

Lewis T Williams

Snezana Drmanac

Michael A Innis

Klaus Giese

David B Kita

Chun Zhang

Ivan Labat

Radomir Crkvenjakov

Mark Dickson

Dena Leshkowitz

Veronica Garcia

Lee William Jones

Yaron Turpaz

Anne B Jefferson

Catalin Barbacioru

David Pot

Altaf Kassam

Birgit Stache-Crain

Rhonda Hansen

Edward J Moler

Venkatakrishna Shyamala

Hong Xin

Greg Harrowe

Sanmao Kang

Mei-Mei Shen

Hamiduddin Khoja

James Diggans

Su Yeon Kim

Daniel Pankratz

Patric Sean Walsh

Joshua Babiarz

Sharlene Velichko

James G Veitch

P Sean Walsh

Darya I Chudova

Anne Bennet Jefferson

The present invention relates to compositions and methods for molecular profiling and diagnostics for genetic disorders and cancer, including but not limited to gene expression product markers associated with cancer or genetic disorders. In particular, the present invention provides algorithms and methods of classifying cancer, for example, thyroid cancer, methods of determining molecular profiles, and methods of analyzing results to provide a diagnosis.

Methods for treatment of thyroid cancer

The present invention relates to compositions, kits, and methods for molecular profiling and cancer diagnostics, including but not limited to genomic DNA markers associated with cancer. In particular, the present invention provides molecular profiles associated with thyroid cancer, methods of determining molecular profiles, and methods of analyzing results to provide a diagnosis.

Methods for classification of tissue samples as positive or negative for cancer

The present disclosure provides systems, methods, and classifiers for differentiating between samples as usual interstitial pneumonia (UIP) or non-UIP.

Methods and systems for detecting usual interstitial pneumonia

The present invention provides methods for sequencing and analysis of nucleic acids and determining that a subject is positive for a non-usual interstitial pneumonia subtype.

Methods for nucleic acid sequencing

The methods disclosed herein can be used to determine sample integrity, such as sample identity, by using kinship coefficients. Kinship coefficients between two samples can be determined by measuring genetic relatedness in order to determine whether the samples are related or not related.

Methods and systems for determining biological sample integrity

Methods and compositions for diagnosis of thyroid conditions

Algorithms for disease diagnostics

Disclosed herein are kits, compositions, and methods relating to the classification of samples. Methods disclosed herein can be used to identify sample mix-ups. Methods disclosed herein can also be used to diagnose conditions or to support treatment-related decisions.

Methods and compositions for classification of samples

The present disclosure provides methods for processing or analyzing a sample of tissue of a subject, to generate a classification of the sample of tissue as positive or negative for thyroid cancer. The present disclosure also provides algorithms and methods of classifying cancer, for example, thyroid cancer, methods of determining molecular profiles, and methods of analyzing results.

Methods for processing or analyzing a sample of thyroid tissue

The present disorders disclosure provides method for processing or analyzing a sample of thyroid tissue of a subject, to generate a classification of the sample of thyroid tissue as positive or negative for thyroid cancer. The present disclosure also provides algorithms and methods of classifying cancer, for example, thyroid cancer, methods of determining molecular profiles, and methods of analyzing results, which may be used to provide a diagnosis.

Methods for processing or analyzing sample of thyroid tissue

The presently claimed invention provides for novel methods and kits for analyzing a collection of target sequences in a nucleic acid sample. A sample is amplified under conditions that enrich for a subset of fragments that includes a collection of target sequences. The invention further provides for analysis of the above sample by hybridization to an array, which may be specifically designed to interrogate the collection of target sequences for particular characteristics, such as, for example, the presence or absence of one or more polymorphisms.

Complexity management of genomic DNA

Growing community of inventors

San Francisco, CA, United States of America

Giulia C Kennedy