La Jolla Institute for Allergy and Immunology

Alk-abello A/s

Alk-abelló, Inc.

Gitte Lund

Alessandro D Sette

Lars Harder Christensen

John Sidney

Peter Sejer Andersen

Bjoern Peters

Henrik Hugo Jacobi

Hans-Henrik Ipsen

Claus Lundegaard

Peter Adler Würtzen

Peter Adler Wurtzen

Thomas Stranzl

The invention relates to novel immunogenic polypeptides identified in house dust mites and storage mites, which have the potential to be used in allergy immunotherapy, for diagnostic purposes, eventually via production of antibodies binding the polypeptide or for characterising allergen extracts of house dust mites and storage mites.

Immunogenic proteins and fragments thereof from allergenic mites

The invention relates to combinations of peptides or variants thereof derived from a portion of an amino sequence of a house dust mite allergen, e.g. the allergens Der p 1, Der f 1, Der p 2 and/or Der f 2. Such peptides comprise at least one T cell epitope and a significant high number of patients in a worldwide population will have HLA alleles with the potential to bind the peptides of the peptide combinations. The invention also relates to the use of such peptide combinations in relieving an immune response caused by a dust mite.

Peptide combinations and uses thereof in treating dust mite allergy

The invention relates to an in vitro method of evaluating the immunological activity of a vaccine preparation in the form of a mixture of a molecular antigen and a carrier, wherein the mixture comprises a liquid phase and a solid phase, to which at least a part of the antigen is attached, the method comprising the steps of

Method of evaluating the immunological activity of a vaccine

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Allerød, Denmark

Gitte Lund