Aventis Research & Technologies Gmbh & Co Kg

Celanese Ventures Gmbh

Axiva Gmbh

Gitte B&ouml;hm

Holger Bengs

J&uuml;rgen Grande

Arnold Schneller

Silke Schuth

Alfred Braunagel

Anette Brunner

The present invention relates to a method for preparing smooth-surface spherical microparticles which are completely or partially made of at least one water-insoluble linear polysaccharide. This method involves dissolving the at least one water-insoluble linear polysaccharide in a solvent or a mixture of solvents, introducing the solution into a precipitation agent or a mixture of precipitation agents, optionally cooling the mixture thus obtained, and separating the microparticles thus formed. The precipitation agent used consists of at least one water-soluble cellulose derivative. This invention also relates to microparticles obtained according to this method.

Method for preparing smooth-surface spherical microparticles completely or partially made of at least one water-insoluble linear polysaccharide and microparticles produced according to this method

Microparticles with a uniform spherical shape and a very narrow size distribution are described. They consist wholly or partly of a linear water-insoluble polysaccharide, preferably of 1,4-&agr;-D-polyglucan, and may contain other, in particular biodegradable, polymers and/or active substances. They are suitable inter alia for the controlled delivery of active substances. They are prepared by dissolving 1,4-&agr;-D-polyglucan or the polysaccharide in a solvent, introducing the solution into a precipitant, cooling the mixture and removing the particles formed.

Spherical microparticles containing linear polysaccharides

The invention relates to a controlled release tablet which in part or as a whole contains water-insoluble linear polysaccharides, preferably the polysaccharide poly(1,4-&agr;-D-glucan), in the form of microparticles, as retardation material. The tablet is also capable of controllably releasing an active agent.

Slow release tablet prepared from linear water-insoluble polysacchrides

The present invention relates to a topical preparation containing spherical microparticles as the essential component, wherein the microparticles comprise water-insoluble linear polyglucan.

Cosmetic or medical preparation for topical use

Biopolymer-based thermoplastic mixture for producing biodegradable shaped bodies

Thermoplastic mixture containing 1,4-&agr;-D-polyglucane, method for making the same and use thereof

Homogeneous mixtures are described and can be processed to give shaped biodegradable and physiologically nonhazardous articles, such as packagings for food or drink or pharmaceutical products, sausage casings and the like. The mixtures comprise dialdehyde starch with a degree of oxidation of greater than 30%, starch which does not exhibit any iodine-starch reaction, and/or modified starch, water and other plasticizers, and also, if desired, other biopolymers and additives.

Growing community of inventors

Frankfurt-am-Main, Germany

Gitte Böhm

Growing community of inventors

Frankfurt-am-Main, Germany

Gitte B&ouml;hm

Gitte Böhm