Novartis Ag

Novartis Pharma Gmbh

Gisbert Weckbecker

Rainer Albert

Christian Bruns

Wilfried Bauer

Ian Lewis

Bernhard Wietfeld

David Bodmer

Mark Meisenbach

Heribert Hellstern

Ivo Felner

Walter Schuler

Hans-Günter Zerwes

Barbara Stolz

Peter Smith-Jones

Hendrik Schuurman

Hans-G&uuml;nter Zerwes

Nagarajan Chandramouli

Johannes Schuurmann Hessel

The invention provides cyclo[{4-(NH&#x2014;CH&#x2014;NH&#x2014;CO&#x2014;O&#x2014;)Pro}-Phg-DTrp-Lys-Tyr(4-Benzyl)-Phe], optionally in protected form, or a pharmaceutically acceptable salt or complex thereof, which has interesting pharmaceutical properties.

Somatostatin analogues

The invention provides cyclo[{4-(NH&#x2014;CH&#x2014;NH&#x2014;CO&#x2014;O-)Pro}-Phg-DTrp-Lys-Tyr(4-Benzyl)-Phe], optionally in protected form, or a pharmaceutically acceptable salt or complex thereof, which has interesting pharmaceutical properties.

This invention relates to the use of 40-O-(2-hydroxy)ethyl-rapamycin for the prevention or treatment of neointimal proliferation and thickening, restenosis, and vascular occlusion following vascular injury.

Use of 40-O-(2-hydroxy)ethylrapamycin for treatment of restenosis and other disorders

A combination of a compound of the somatostatin class and a rapamycin macrolide is useful for the prevention or treatment of cell hyperproliferation.

Combination of a somatostatin analogue and a rapamycin

Peptides

Somatostain analogues comprising the amino acid sequence of the formula (I): -(D/L)Trp-Lys-X,-X,, wherein X,is a substituted Thr, Ser, Tyr, Glu or Cys residue and X,is an &agr;-amino acid having an aromatic residue on the C,side chain, or an amino acid unit selected from Dab, Dpr, Dpm, His (Bzl)HyPro, thienyl-Ala, cyclohexyl-Ala and t.-butyl-Ala, the residue Lys of said sequence corresponding to the residue Lys,of the native somatostatin-14, in free form, in salt form or complexed with a detectable element have interesting pharmacological properties.

Somatostatin peptides

Chelated peptides, complexes thereof, pharmaceutical compositions containing them and their use as radiopharmaceuticals

Growing community of inventors

Biel-Benken, Switzerland

Gisbert Weckbecker