Ohio State Innovation Foundation

The Ohio State University

Gireesh Rajashekara

Sally Miller

Yosra A Helmy

Dipak Kathayat

James Fuchs

Loic Deblais

Xiulan Xu

Corey Nislow

Zilu Wan

Janet Antwi

Anand Kumar

Ulyana Munoz Acuna

Esperanza Carcache De Blanco

Melvin Pascall

Loïc Deblais

Disclosed herein are methods of treating a subject with a bacterial infection, or preventing a bacterial infection, comprising administering to the subject an effective amount of at least one compound, or a derivative thereof, having the formula of SM1, SM3, SM4, or SM5. Also described are methods of inhibiting bacterial growth in a plant comprising contacting the plant with an effective amount of at least one compound, or a derivative thereof, having the formula of SM1, SM3, SM4, or SM5. The methods are effective against an array of bacterial pathogens in various animals and plants.

Methods to control infection using new generation small molecule growth inhibitors

Disclosed are anti-avian pathogenic(APEC) agents as well as methods of using thereof.

Compounds, compositions, and methods for the treatment and prevention of avian pathogenic(APEC)

Compounds and compositions of matter are provided that are small molecule antimicrobials. The compounds are selected from JH-144, TH-04 or TH-08 or combinations thereof. Compositions of matter are provided which in an embodiment may comprise a carrier, and in further embodiments may comprise a pharmaceutically acceptable excipient, film, biofilm or edible film. Methods of use are provided in which the composition may be administered to a subject in need thereof, and in an embodiment where the subject has a bacterial infection. Other embodiments provide the composition may be contacted with surface to eliminate or reduce bacteria.

Small molecule antimicrobials

The subject matter disclosed herein generally relates to modulators ofsubsp., derivatives thereof, formulations thereof, coated seeds, and methods of using such compounds to treat diseases such as bacterial canker in plants.

[object Object]

subsp.(Cmm) is an important Gram-positive-bacterial pathogen that infects tomato plants causing wilting and cankers and leading to severe economic losses in commercial tomato production worldwide. In order to visualize the infection process of Cmm in germinating seeds, bioluminescent Cmm strains were constructed by transforming the lux reporter gene into the bacterium. A vector pXX2 was constructed by inserting a modified promoterless lux-operon to a Cmm transposon mutagenesis vector, pKGT452C&#x3b2;. After electroporation, pXX2 carrying the Cmx::luxABCDE::Tn1409 cassette resulted in insertion of lux-operon into the Cmm chromosome. The virulent, stable, constitutively bioluminescent strain BL-Cmm17 was selected for further characterization of growth properties and inoculation on tomato seeds. Using this bioluminescent strain, Cmm colonization dynamics of germinating seeds were monitored in real-time using the in vivo imaging system (IVIS).

Methods and compositions relating to bioluminescent microorganisms

Growing community of inventors

Wooster, OH, United States of America

Gireesh Rajashekara