Blaschim S.p.a.

Blasinachim S.p.a.

Biaschim S.p.a.

Giovanni Villa

Claudio Giordano

Fulvio Uggeri

Aldo Belli

Oreste Piccolo

Enrico Zen

Graziano Castaldi

Attilio Citterio

Process for preparing esters of alkanoic acids via rearrangement of alpha-haloketals in the presence of a Lewis acid. The rection is preferably carried out in the presence of catalytic amounts of a Lewis acid and of a diluent at a temperature in the range from about 0.degree. to the reflux temperature of diluent. The esters thus obtained are useful as intermediate products for preparing drugs. The process involves the preparation of new alpha-haloketals.

Process for preparing esters of alkanoic acids via rearrangement of

Process for preparing alkanoic acid or their esters by rearrangement of alpha-halo-ketones in protic medium and in the presence of a non-noble metal salt. The protic medium is preferably an aliphatic alcohol having low molecular weight or water and the reaction is carried out at a temperature from 0.degree. C. to the boiling-point of the diluent or of the diluents mixture.

Process for preparing alkanoic acids or esters thereof by rearrangement

Process for preparing esters of 2-(6'-methoxy-2'-naphtyl)-propionic acid via rearrangement of new ketals of 2-halo-1-(6'-methoxy-2'-naphtyl)-propan-1-one in the presence of a Lewis acid. The esters thus obtained are useful as intermediate products for preparing Naproxen. The process involves the preparation of the following new compounds:

Process for preparing esters of 2-(6'-methoxy-2'-naphtyl)-propionic acid

Preparation of esters of 2-(6'-methoxy-2'-naphthyl)-propionic acid via

Process for the optical resolution of (.+-.)2-(6'methoxy-2'-naphthyl)-propionic acid by adding from 0.45 to 0.65 mole of (S)-alpha-phenylethylamine to each mole of said acid in chloroform.

Process for the optical resolution of

Improvement in the process for preparing biaryl compounds via coupling of an arylamine with an arene in the presence of a nitrite, an acid and copper metal or a derivative thereof; the improvement is consisting in adding to the reaction mixture a trialkylorthoformate. The process may be used for preparing drugs such as Flurbiprofen and Xenbucin or intermediate compounds particularly useful for preparing Flurbiprofen, Flufenisal, Chlordimorin, Xenbucin, Xenysalate, Xenyhexenic acid and the like.

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Monticello Brianza, Italy

Giovanni Villa