Farmitalia Carlo Erba

Other

Giovanni Rivola

Giuseppe Cassinelli

Sergio Merli

Arpad Grein

Teresa Bordoni

##STR1## are prepared by a biosynthetic process based on the addition of sodium salt of 1,3-N,N-dimethylbarbituric acid and 2-thiobarbituric acid respectively during the fermentation process of different micro-organisms such as Streptomyces peucetius and its mutants. The novel compounds are provided with good antibacterial and antitumour activity.

Biosynthetic anthracyclines related to daunorubicin

4'-Deoxy-13(S)-dihydro-4'-iododoxorubicin having the formula (II): ##STR1## and pharmaceutically acceptable salts thereof are anti-tumor agents.

New antitumor agent obtained by microbial stereoselective reduction of

Anthracycline glycosides W, X, Y and Z which are prepared by the fermentation of mutant F.I. 416 of Streptomyces peucetius var. caesius. The new compounds are useful against both gram positive and gram negative bacteria and as antitumor agents.

Antitumor antibiotics

Anthracycline antibiotics of the formula: ##STR1## wherein R is --CO--CH.sub.2 OH, --CHOH--CH.sub.3, --CO--CH.sub.3 or --CH.sub.2 --CH.sub.3 having antitumor and antibacterial activity are prepared by culturing a new mutant strain of microorganism designated as Micromonospora peucetica sp. nova and which has been deposited with the American Type Culture Collection under number No. 31366 ATCC.

Preparation of II-deoxy anthracycline antibiotics

11-Deoxy-carminomycin compounds

Anthracycling antibiotics of the formula: ##STR1## wherein R is --CO--CH.sub.2 OH, --CHOH--CH.sub.3, --CO--CH.sub.3 or --CH.sub.2 --CH.sub.3 having antitumor and antibacterial activity are prepared by culturing a new mutant strain of microorganism designated as Macromonospora peucetica sp. nova and which has been deposited with the American Type Culture Collection under numbr No. 31366 ATCC.

Growing community of inventors

Milan, Italy

Giovanni Rivola