Antibioticos S.p.a.

Giovanni Pozzi

Marco Alpegiani

Walter Cabri

Loris Sogli

Davide Longoni

Ermanno Bernasconi

Enrico Siviero

Daniele Mario Terrassan

Francisco Salto

Patricio Martin Gomez

Angelo Bedeschi

Roberta Pizzocaro

Paolo Ghetti

Gaetano Balsamo

Ettore Negri

Disclosed is a crystalline form of irinotecan hydrochloride (I) and processes for the preparation thereof from crude irinotecan hydrochloride or another polymorphic form of irinotecan. Said crystalline form is particularly suitable for industrial use, because it is easily filtered and possesses characteristics of high stability and purity. 

Crystalline irinotecan hydrochloride and methods for its preparation

Disclosed are salts of the general formula (I) wherein R, Rand B are defined in the description. These salts are useful intermediates for the preparation of cefdinir. Also, disclosed are processes for the preparation thereof from the compounds of the general formula (II) and (III).  Further, disclosed is a method of producing cefdinir from the salts of the general formula (I) including the steps of removing protecting groups.

Intermediate cefdinir salts

Cefdinir crystalline salts of formula (I), in which n ranges from 1 to 3, the preparation and use thereof for the preparation and purification of cefdinir are herein disclosed. The salts of formula (I) can be obtained from cefdinir intermediates or crude cefdinir by treatment with phosphoric acid.

Crystalline cefdinir salts

A compound having the following general formula (I): ##STR1## where R is a hydrogen atom; a linear or branched C.sub.1 -C.sub.4 alkyl group, unsubstituted or substituted by at least a phenyl group or at least a hydrogen atom; a benzyl group substituted by at least a linear or branched C.sub.1 -C.sub.4 alkyl or alkoxy group or a nitro group; a silyl substituted by at least a linear or branched, unsubstituted or substituted C.sub.1 -C.sub.4 alkyl group; n is 0 or 1; and Y is a radical of formula ##STR2## wherein A is H, OH, Cl, CH.sub.2, CH.sub.2 X, where X is F, Cl, Br, I, OH or OR' and R' is COCH.sub.3 or a linear or branched, unsubstituted or substituted C.sub.1 -C.sub.4 alkyl group and - - - represents a single or a double bond, with the proviso that when n=0 and R is H, R' is not a methyl group.

Glutaryl 7-ACA derivatives and processes for obtaining them

Growing community of inventors

Besana Brianza, Italy

Giovanni Pozzi