Johns Hopkins University

Duke University

Becton Dickinson and Company Limited

Giovanni Parmigiani

Bert Vogelstein

Kenneth W Kinzler

Nickolas Papadopoulos

Darell D Bigner

Victor E Velculescu

Hai Yan

Gregory J Riggins

Chien-Tsun Kuan

D Williams Parsons

Rebecca J Leary

Jimmy Cheng-Ho Lin

Timothy M Wiles

Ralph Hruban

Sian Jones

Scott E Kern

Michael Goggins

Xiaosong Zhang

Philipp Angenendt

Rachel Karchin

Michael A O'connell

Michael A O'Connell

David J Turner

James R Eshleman

Alison Klein

Merlise Clyde

Donald William Parsons

Williams Parsons

Kenneth Kinzler

Jimmy Chang-Ho Lin

Darell Bigner

Victor Velculescu

We found mutations of the R132 residue of isocitrate dehydrogenase 1 (IDH1) in the majority of grade II and III astrocytomas and oligodendrogliomas as well as in glioblastomas that develop from these lower grade lesions. Those tumors without mutations in IDH1 often had mutations at the analogous R172 residue of the closely related IDH2 gene. These findings have important implications for the pathogenesis and diagnosis of malignant gliomas.

Genetic alterations in isocitrate dehydrogenase and other genes in malignant glioma

We found mutations of the R132 residue of isocitrate dehydrogenase 1 (IDH1) in the majority of grade II and III astrocytomas and oligodendrogliomas as well as in gliblastomas that develop from these lower grade lesions. Those tumors without mutations in IDH1 often had mutations at the analogous R172 residue of the closely related IDH2 gene. These findings have important implications for the pathogenesis and diagnosis of malignant gliomas.

A system and method for analyzing samples, such as biological samples, to accurately and effectively determine the susceptibility of the samples to antimicrobial materials, so as to determine minimum inhibitory concentration (MIC) values for the respective samples and antimicrobial materials. At each of a plurality of time intervals, the system and method directs a plurality of different analyzing light wavelengths, such as red, green and blue wavelengths, onto each of a plurality of sample wells, and detects a respective resultant light wavelength emanating from the respective sample wells for each of the analyzing light wavelengths. The system and method uses resultant light wavelengths to generate at least two growth indicator characteristic curves representing, for example, the redox state and turbidity characteristics of the sample wells. The system then uses the redox state and turbidity characteristics of sample wells containing the same antimicrobial material to determine the MIC value for that material in relation to the sample contained in those wells.

System and method for analyzing antibiotic susceptibility of biological samples using redox and turbidity measurments to ascertain minimum inhibitory concentrations (MICs)

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Baltimore, MD, United States of America

Giovanni Parmigiani