Sigma-tau Industrie Farmaceutiche Riunite S.p.a.

UniversitÁ Degli Studi Di Genova

Istituto Europeo Di Oncologia S.r.l.

Giovanni Paganelli

Marco Chinol

Mauro Ginanneschi

Paolo Carminati

Umberto Veronesi

Sergio Cafaggi

Paola Cirrincione

Brunella Parodi

Gabriele Caviglioli

Eleonora Russo

A container for a vial of radiopharmaceutical, made of polymethyl methacrylate consists of a receptacle, with a cavity capable of containing the vial of radiopharmaceutical, and of a lid screwed onto the receptacle for closing the container, said lid presenting a central through-hole. A set, in combination with this container with the vial of radiopharmaceutical, consisting of a bottle of saline solution and two infusion catheters, enhances the radioprotection during the infusion of a radiopharmaceutical in an infusion operation.

Container for vial of radiopharmaceutical and set for its infusion in a patient or for its transfer elsewhere

Formula (I) compounds are described where the groups are as defined here below, processes for their preparation, and their uses for the preparation of conjugates with radionuclides for use in human and animal therapy and diagnostics, particularly for the diagnosis and therapy of pathological conditions such as tumours.

Aminoderivative of biotin and their conjugates with macrocyclic chelating agents

The present invention describes the use of an agent endowed with tumour tropism in combination with another agent with anticancer activity and with an affinity for the first agent for the preparation of a medicament useful for the two-step perioperative therapy of solid tumours. The advantages of the present invention consist in the greater, effective localisation of its anticancer activity, in the reduction of the number of administration steps and in the possibility of reducing the anticancer doses, with a resulting decrease in side effects, but without any loss of efficacy.

Medicament for the two-step perioperative therapy of solid tumours

Formula (I) compounds are described: Formula (I) where the radicals are as defined in the description, processes for their preparation, and their uses for the preparation of conjugates with radionuclides for use in human and animal therapy and diagnostics, particularly for the diagnosis and therapy of pathological conditions such as tumors.

Biotin diaminoderivatives and their conjugates with macrocyclic chelating agents

Formula (I) compounds are described where the groups are as defined here below, processes for their preparation, and their uses for the preparation of conjugates with radionuclides for use in human and animal therapy and diagnostics, particularly for the diagnosis and therapy of pathological conditions such as tumours 

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Milan, Italy

Giovanni Paganelli