Societa Italo-britannica L. Manetti-h. Roberts & C.

Societa Italo-britannica-l. Manetti-h. Roberts Co.

Societa Italo-britannica

Giovanni Orzalesi

Renato Selleri

Franco Innocenti

Ivo Volpato

Compounds which are derivatives of 2-amino-5-(o-sulphamidophenyl)-1,3,4-thiadiazol of formula ##STR1## wherein R is a hydrogen atom or a --CH.sub.3, --C.sub.2 H.sub.5, iso--C.sub.3 H.sub.7, n--C.sub.4 H.sub.9 or --CH.sub.2 --CH.dbd.CH.sub.2 group and R.sub.1 is a hydrogen atom or a --CH.sub.3 or --C.sub.2 H.sub.5 group, are active agents against virus infections in higher animal organisms.

Derivatives of 2-amino-5-(o-sulphamidophenyl)-1,3,4-thiadiazol as

L-arginine D,L-pyroglutamate has a tonic activity at the neuro-endocrinal level with a specific effect in enhancing sexual behavior of Mammalia males, particularly in individuals of elderly age, humans being included. To be used in the pharmaceutical and veterinary field.

L-Arginine D,L-pyroglutamate as a pharmaceutical agent having an

There are prepared 4-hydroxy-isophthalic acid bis (3- or 4-picolyl-amides) of the formula (I) ##STR1## where R' is H or an aliphatic or alicyclic hydrocarbon group with 1 to 16 carbon atoms, R'''' is 3-pyridyl or 4-pyridyl, R''' is H, Cl, NO.sub.2, or --OCH.sub.3, R'' is an aliphatic or alicyclic hydrocarbon group with 1 to 8 carbon atoms with the exception that when R'''' is 3-pyridyl and R' and R''' are both H, then R'' is an aliphatic or alicyclic hydrocarbon radical with 3 to 8 carbon atoms. The compounds are useful in inhibition of blood platelet aggregation.

Substituted 4-hydroxy-isophthalic acid picolylamides having a

The object of the invention is a new chemical compound 2-(4- isobutylphenyl)propiohydroxamic acid, having valuable analgesic, antipyretic and antiinflammatory properties, and a procedure for its synthesis.

2-(4-Isobutylphenyl)-propiohydroxamic acid and a procedure for its

2-(4-Isobutylphenyl)-propiohydroxamic acid is prepared by mixing anhydrous methanol with 2-(4-isobutylphenyl)-propionitrile, saturating the mixture with dry hydrogen chloride, reacting, diluting the reaction product with ethyl ether, reacting the precipitate with hydroxylamine hydrochloride in methanol and with 50% NaOH, stirring, diluting with water and precipitating with carbon dioxide.

Process for the preparation of 2-(4-isobutylphenyl)-propiohydroxamic acid

There is prepared the compound N,N'-bis-(3-picolyl)-4-methoxy-isophthalamide. It is useful as an inhibitor of blood plate aggregation.

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Florence, Italy

Giovanni Orzalesi