Polifarma S.p.a.

Eniricerche S.p.a.

Other

Enichem Elastomeri S.p.a.

Giovanni Di Stazio

Giovanna De Luca

Vincenzo Politi

Mario Materazzi

Andrea Margonelli

Antonio S Verdini

Alessandro Sisto

Antonino Virdia

Silvana D'Alessio

Valerio Caciagli

Vincenzo Polita

Vencenzo Politi

Antonio Virdia

Peptidomimetic compounds capable of inhibiting zinc-dependent metalloproteinases to treat pathological conditions associated with activation of endogenous metalloproteinases in mammals.

Inhibitor compounds of zinc-dependent metalloproteinases associated with

A method for determining the therapeutic potential of peptidomimetic compounds as inhibitors of zinc-dependent metalloproteinase activity associated with pathological conditions of humans and animals.

Method for determining the therapeutic activity of metalloproteinase

Compounds of general formula A--B--C in which: A is a monovalent radical of a L-ring molecule; B is a bivalent radical of a L-.alpha.-aminoacid; and C is a monovalent radical of a L-aromatic molecule. The compounds show an anti-hypertensive, analgesic, immuno-modulating and antiinflammatory activity, they are resistant to enzyme hydrolysis and they can be used for the preparation of drugs for oral administration.

Peptide compounds of (L) amino acids and ring molecules, and

Compounds of general formula A--B--C in which: A is a monovalent radical of a laevorotatory ring molecule; B is a bivalent radical of a laevorotatory .alpha.-aminoacid; and C is a monovalent radical of a laevorotatory aromatic molecule. The compounds show an anti-hypertensive, analgesic, immuno-modulating and antiinflammatory activity, they are resistant to enzyme hydrolysis and they can be used for the preparation of drugs for oral administration.

Compounds with a sequence of three radicals, the central one being .alpha.-

3-indolepyruvic acid is an active agent in preventing cerebral damage caused by stress and ageing and induced by an excessive presence in the blood of glucocorticoids, secreted by the adrenal gland.

Method for reducing the level of glucocorticoids in the blood and

3-indolepyruvic acid derivatives substituted on the benzene moiety show good antagonizing activity on excitatory aminoacids and on free radicals, for which reason they are therapeutic agents in cerebral and peripheral degenerative pathologies. Their method of production by passage through the corresponding substituted triptophane.

Tryptophane and 3-indolepyruvic acid, methods of production therefor

Uridine is used to treat the peripheral complications of diabetes, such as neuropathy, retinopathy and vasculopathy, thanks to its characteristics of promotor of glycogen endocellular biosynthesis. 40 diabetic patients were treated for six months with uridine or with placebo in a double-blind clinical teat.

Use of uridine in the pharmacological treatment of the peripheral

Compounds of peptide nature presenting a sequence of three aminoacids, in particular with PYR and TRP as terminal groups, are found to be active as immunomodulating agents.

Method of treatment with tripeptide pharmaceutical compositions as

A description is given of the cosmetic use of 3-indolepyruvic acid for the protection of the skin from damage caused by oxygen, by the sun and by aging.

Cosmetic use of 3-indolepyruvic acid

Tripeptides having hypotensive activity, defined by the following general formula:

Tripeptide compounds having hypotensive activity

3-indolepyruvic acid derivatives and pharmaceutical use thereof

Disorders due to an altered balance of dopamine release by the cerebral dopaminergic system, such as schizophrenia and Parkinson's disease, can be treated by administration of uridine which is a specific agent for the protection of the cholecystokinin level in the brain tissue.

Pharmacological use of uridine in the treatment of nervous disorders

New decapeptides having hypotensive action are disclosed, which can be defined by the formula:

Decapeptides having hypotensive action and process for their preparation

Production of indolepyruvic acid and the 5-hydroxy derivative thereof

Pharmacologically active tripeptides, with at least a retro-inverted peptidic bond, definable by means of the following general formulae: ##STR1## their pharmaceutically acceptable salts, esters or alkyl amides, wherein

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Rome, Italy

Giovanni Di Stazio