Dompe Pha.r.ma S.p.a.

Giovanni Del Re

Cesare Di Palma

Matteo Putrignano

Gabriele Di Giacomo

An apparatus is described for micron and submicron particles formation of a substance using the GAS process, comprising a particles formation vessel () and means for introducing a solution of the substance and a supercritical fluid into the particles formation vessel (), wherein said means comprise a nozzle () having a central orifice () serving to carry a flow of solution, and a plurality of separate outer orifices () serving to carry a flow of pure supercritical fluid or a flow of supercritical fluid mixed with a modifier, such that the solvent is extracted from the solution by the supercritical fluid and precipitation of micron and submicron particles occurs. Also a process is described, carried out with such an apparatus.

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Monteluco di Roio, Italy

Giovanni Del Re