Bracco Imaging S.p.a.

Kao Corporation

Giovanni Battista Giovenzana

Silvio Aime

Luciano Lattuada

Fulvio Uggeri

Roberta Napolitano

Massimo Visigalli

Valeria Boi

Camilla Cavallotti

Alberto Fringuello Mingo

Magnus Karlsson

Fabio Tedoldi

Pernille Rose Jensen

Mathilde H Lerche

Luisella Calabi

Massimo Sisti

Giovanni Palmisano

Rolf E Swenson

Pier Lucio Anelli

Alessandro Maiocchi

Carlo Felice Viscardi

Enzo Terreno

Pierfrancesco Morosini

Daniela Delli Castelli

Keiji Monda

Alfonso Nardelli

Pietro Delogu

Simona Ghiani

Sonia Colombo Serra

Francesca Reineri

Luisa Poggi

Roberto Gobetto

Alberto Vertova

Simona Baroni

Carlo Morelli

Letizia Sorti

Alessandro Minguzzi

Marco Crosetti

Carlo Nervi

Ramalingam Kondareddiar

Walter Dastru′

Daniela Santelia

Alessandra Viale

Fabrizio Goffredi

Ivan Menegotto

Walter Dastru'

The invention is related to a process for preparing a iodinating X-rays contrast agent. More specifically, it relates to a process for the preparation of N,N'-bis-(2,3-dihydroxypropyl)-5-hydroxy-2,4,6-triiodo-1,3-benzenedicarboxaniide (I) by electrochemical iodination of N,N′-(2,3-dihydroxypropyl)-5-hydroxy-1,3-benzenedicarboxamide (II) with molecular iodine (I2) which is in situ electrochemically generated from a source of iodide ions (I−). The iodide ions (I−) are obtained by the dissolution of hydrogen iodide (HI) or an alkali metal iodide in the reaction medium or produced during the reaction of N,N′-(2,3-dihydroxypropyl)-5-hydroxy-1,3-benzenedicarboxamide with I2. The invention also relates to the use of the intermediate compound of formula (I), obtained through the above electrochemical iodination of compound (II), in the preparation of N,N′-bis[2,3-dihydroxypropyl]-5(hydroxyacetyl)methylamino]-2,4,6-triiodo-1,3-benzenedicarboxamide (iomeprol).

Electrochemical iodination of N,N'-(2,3-dihydroxypropyl)-5-hydroxy-1,3-benzenedicarboxamide

The present invention relates to new class of functionalized macrocycles capable of chelating paramagnetic metal ions, their chelated complexes with metal ions and the use thereof as contrast agents, particularly suitable for Magnetic Resonance Imaging (MRI) analysis.

Contrast agents

The present invention relates to new class of functionalized polyazamacrocycles including at least one phosphonic or phosphinic group linked to a nitrogen atom of the macrocyclic cage, and capable of chelating paramagnetic metal ions, their chelated complexes with metal ions and the use thereof as contrast agents, particularly suitable for Magnetic Resonance Imaging (MRI) analysis.

The present invention relates to new class of dimeric macrocycles capable of chelating paramagnetic metal ions, their chelated complexes with the paramagnetic metal ions and the use thereof as contrast agents, particularly suitable for Magnetic Resonance Imaging (MRI) analysis.

Dimeric contrast agents

The present invention generally relates to a process for the preparation of aqueous solutions of hyperpolarized molecules ready for use in in-vivo MR diagnostic imaging, the use thereof as MRI contrast agent in investigation methods for producing diagnostic MR images of a human or non-human animal body organ, region or tissue.

Process for preparing hyperpolarized substrates and method for MRI

The present invention relates to a process for the preparation of aqueous solutions of hyperpolarized carboxylic organic acids ready for use in in-vivo MR diagnostic imaging, and the use of the corresponding anhydrides or esters as glass-forming agents.

Process for the preparation of hyperpolarized derivatives for use in MRI analysis

The present invention relates to a process for the preparation of iodinated phenols, &#x2014;in particular, it relates to a process including the electrochemical iodination of 3,5-disubstituted phenols of formula (1) to the corresponding 3,5-disubstituted-2, 4,6-triiodophenols of formula (2), which are useful intermediates for the synthesis of x-ray contrast media, and to the preparation of the contrast media themselves. Furthermore, the present invention includes the electrochemical iodination of 3, 5- disubstituted anilines of formula (6) to the corresponding 3,5-disubstituted-2,4,6-triiodoanilins of formula (7). 

Process for the iodination of aromatic compounds

The present invention describes a process for the synthesis of a iodinating agent, being said iodinating agent iodine chloride (ICI.) In particular, the present invention relates to a process for the electrochemical preparation of ICI, as a useful iodinating agent in the preparation of iodinated organic compounds for use as contrast agents or their precursors in the synthesis of the same.

Process for the preparation of a iodinating agent

The invention relates to a one-step process for the preparation of aqueous solutions of hyperpolarized molecules in which, in a single step, the said hyperpolarized molecules are separated from the crude solution by means of a fast phase-transfer extraction and isolated in an impurity-free aqueous solution, ready for use in the MRI diagnostic imaging of organs, region or tissues of the human or animal body.

Process for the preparation of aqueous solutions of hyperpolarized molecules

Disclosed are CEST paramagnetic agents comprising a substrate (SH) containing mobile protons bonded to a paramagnetic chelate (SR) containing a metal selected from iron (11) (high-spin configuration), iron (111), cobalt (11), rhodium (11), copper (11), nickel (11), cerium (111), praseodymium (111), neodymium (111), dysprosium (111), erbium (111), terbium (111), holmium (111), thulium (III), ytterbium (III) and europium (111).

Adducts between magnetic resonance shift reagents and substrates containing exchangeable protons for 'cest' applications

Compounds of general formula (I): with substituents as defined herein and their chelates with bi-trivalent ions of the metal elements of atomic numbers 20 to 31, 39, 42, 43, 44, 49, and 57 to 83, and radioisotopes chosen amongPb,Ga,Ga,As,In,In,Y,Ru,Cu,Cu,Fe,Mn,La,Yb,Sm,Ho,Pm,Lu,Pr,Gd,Bi,Sc,Pm,Cu,Ag,Au,Tb,Cr,Tm,Ce,Yb,Y,Dy,Dy,Ru,Ru,Re,Tc,Bi,Bi,Bi,Rh,Pd,Sn,Sn andAu, as well as the salts thereof with physiologically compatible bases or acids.

Multidentate AZA ligands able to complex metal ions and the use thereof in diagnostics and therapy

A hair dye composition including a first part containing an alkaline agent and a second part containing an oxidizing agent, which are mixed together immediately before use, wherein at least one of the first part and the second part contains a diazacycloheptane represented by the following general formula (1) or a salt thereof, and the pH of the mixture is 7.5 to 12; 

Hair dye composition

Compounds of general formula (I): in which: Ris hydrogen, C&#x2013;Calkyl, C&#x2013;Ccycloalkyl, C&#x2013;Ccycloalkylalkyl, aryl, arylalkyl, or two R1, taken together, form a straight or cyclic C&#x2013;Calkylene group or an ortho disubstituted arylene; Ris hydrogen, C&#x2013;Calkyl, C&#x2013;Ccycloalkyl, C&#x2013;Ccycloalkylalkyl, aryl or aryl alkyl optionally substituted with functional groups which allow conjugation with a suitable molecule able to interact with physiological systems; R, Rand Rare hydrogen, C&#x2013;Calkyl, C&#x2013;Ccycloalkyl, C&#x2013;Ccycloalkylalkyl, aryl, arylalkyl; and their chelates with bi-trivalent ions of the metal elements having atomic number ranging between 20 and 31, 39, 42, 43, 44, 49, and between 57 and 83, and radioisotopes chosen amongPbGaGaAsInInYRuCuCuFeMnLaYbSmHoPmLuPrGdBiScPmCu,Ag,Au,Tb andCr as well as the salts thereof with physiologically compatible bases or acids 

Multidentate aza ligands able to complex metal ions and the use thereof in diagnostics and therapy

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Novara, Italy

Giovanni Battista Giovenzana