UniversitÁ Degli Studi Di Genova

Centro Biotecnologie Avanzate

Giovanna Basile

Umberto Benatti

Antonio De Flora

Elena Zocchi

Santina Bruzzone

Luisa Franco

Lucrezia Guida

Mirko Magnone

Gianluca Damonte

Annalisa Salis

Ernesto Fattorusso

Orazio Taglialatela-Scafati

Sonia Scarfi′

Iliana Moreschi

Sonia Scarfi'

The invention relates to novel adenyl dinucleotides which are isomers of the dinucleotide Ap2A, having formulae (I) and (II). The dinucleotides of the invention have antitumour activity, particularly against tumours of haematological origin, such as for example leukaemias and lymphomas. The invention further relates to the use of such dinucleotides as antitumour medicaments. Finally, the invention relates to an enzymatic method for preparing the dinucleotides of formulae (I) and (II) and to an enzymatic assay method for the dinucleotide of formula (I) which is based on its complete conversion to NAD. 

Adenyl dinucleotides with antitumour activity and a method of preparing thereof

The invention relates to a novel use of fluridone&#x2014;compound known per se and used as an aquatic erbicide&#x2014;in the medical field, in particular as an active compound for preparing a medicament having anti-inflammatory activity. Pharmaceutical compositions comprising fluridone as an active compound and pharmaceutically acceptable carriers and/or diluents are also disclosed. Finally, there is disclosed the pro-inflammatory activity of abscisic acid (ABA), a plant hormone which is also found in mammal serum and against which fluridone acts an inhibitor.

Fluridone as an anti-inflammatory agent

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Genoa, Italy

Giovanna Basile