Montedipe S.p.a.

Bracco Industria Chimica, S.p.a.

Istituto Chemioterapico Italiano S.p.a.

Bracco Chimica S.p.a.

Giorgio Vittadini

Fulvio Uggeri

Ernst Felder

Luciano Fumagalli

Annibale Vezzoli

Gianfranco Biglione

Gian C Fasulo

Aldo Garzia

Andrea Bottazzi

Andrea Mattiussi

Costantino Coccoli

Domenico Pelagalli

Comounds having the formula ##STR1## wherein: a is 2 or 3; b is an integer from 0 to 4;

Paramagnetic chelates

Blends based on vinyl-aromatic polymers endowed with high tenacity and good chemical resistance, comprising:

Blends based on vinyl-aromatic polymers endowed with high tenacity and

Compounds suitable for NMR imaging having the formula: ##STR1## wherein a is 2 or 3;

Paramagnetic chelates useful for NMR imaging

Polymeric blends based on vinyl-aromatic polymers endowed with high tenacity and chemical resistance comprising:

Polymeric blends based on vinyl-aromatic polymers endowed with high

There is disclosed the reduction of alkyl esters of carbonic-carboxylic acid anhydrides at elevated temperature and pressure in the presence of platinum group metal catalysts, especially palladium on activated carbon, to make alcohols. Novel alkyl esters of carbonic-carboxylic acid anhydrides are disclosed, and can be used to make the corresponding alcohols, e.g., substituted benzyl alcohols. The alcohols can be converted to the corresponding halo, e.g., chloro, compounds. The substituted benzyl halides can be reacted with di(lower alkoxy)propionitriles, and the resulting 5-benzyl pyrimidines such as trimethoprim, 2,4-diamino-5-(3,4,5-trimethoxybenzyl)-pyrimidine, which is a known anti-bacterial agent, are especially useful in combination with sulfa drugs such as sulfamethoxazole. Other alcohols that can be made in accordance with the invention include 2,6-pyridine dimethanol which can be used to make pyridinol carbamate, an anti-inflammatory agent and an anti-arteriosclerotic agent and 1-aceto-4-hydroxymethyl-5-methyl imidazole, which can be converted into cimetidine.

Reduction of alkyl esters of carbonic-carboxylic anhydrides to alcohols

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Milan, Italy

Giorgio Vittadini