Zach System

Wyeth

Zambon Group

Zach Systems S.p.a.

F.i.s. Fabbrica Italiana Sintetici S.p.a.

Giorgio Soriato

Massimo Verzini

Livius Cotarca

Pietro Allegrini

Johnny Foletto

Vincenzo Cannata

Roberto Giovanetti

Giuseppe Barreca

Roberto Brescello

Massimiliano Forcato

Nicola Catozzi

Paolo Maragni

Fabio Bassan

Paolo Andreella

Francesco Tasinato

Marco Demo

Daniele Urbani

Marco Villa

Maurizio Paiocchi

Aldo Belli

Kadum A Ali

Raffaella Volpicelli

Andrea Nicoli

Ivan Michieletto

Francesco Corcella

Valeriano Merli

Katiuscia Arrighi

Giorgio Sagramora

Malama K Chibwe

Shridhar G Gangolli

Carl E Longfellow

Enrico Pace

Fabio Belluzzo

A process for preparing N-[(1R)-1-(1-naphthyl)ethyl]-3-[3-(trifluoromethyl)-phenyl]propan-1-amine hydrochloride salt of formula (I) i.e. Cinacalcet hydrochloride and its intermediates of formulae (VII) and (VIII) wherein Z is chloride or another pharmaceutically acceptable anionic counterion.

Process for preparing Cinacalcet hydrochloride

The present invention relates to a process for preparing gabapentin and, more particularly, it relates to a process for the direct extraction of gabapentin from an aqueous solution derived from the Hofmann rearrangement of 1,1-cyclohexanediacetic acid monoamide.

Process for preparing gabapentin

The present invention relates to a process for preparing Nebivolol and, more in particular, to a fractional distillation method of a mixture of stereoisomers of formula intermediates useful in the preparation of nebivolol.

Process for preparing nebivolol

The present invention relates to a process for preparing Nebivolol and, more particularly, to an improved method of debenzylation of a compound of formula (II) useful for preparing nebivolol endowed with high purity. 

Process for preparing Nebivolol

A process for preparing N-[(1R)-1-(1-naphthyl)ethyl]-3-[3-(trifluoromethyl)-phenyl]propan-1-amine of formula hydrochloride salt of formula (I) i.e. Cinacalcet.HCl and its intermediate of formula (IX) 

Process for preparing cinacalcet

The present invention relates to methods of preparing polymorphic Form A of bazedoxifene acetate and polymorphic Form A prepared by such methods.

Methods of preparing polymorphic form A of bazedoxifene acetate

A process for preparing N-[(1R)-1-(1-naphthyl)ethyl]-3-[3-(trifluoromethyl)-phenyl]propan-1-amine of formula (I) i.e. Cinacalcet and its intermediates of formulae (V), (Va) and (Vb). 

Process for preparing Cinacalcet

The present invention relates to a process for the preparation of gabapentin and, more in particular, to a method of synthesis of 1,1-cyclohexane acetic acid monoamide, an intermediate used in the preparation of gabapentin, comprising the basic hydrolysis reaction of &#x3b1;,-diaminocarbonyl-&#x3b2;,&#x3b2;-pentamethylene glutarimide.

Process for the preparation of gabapentin

The present invention is directed to a crystalline polymorph of bazedoxifene acetate, compositions containing the same, preparations thereof, and uses thereof.

Crystalline polymorph of bazedoxifene acetate

The present invention relates to a process for the preparation of gabapentin and, more particularly, it relates to a precipitation process of gabapentin by acidification of an aqueous solution deriving from the Hofmann rearrangement of 1,1-cyclohexanediacetic acid monoamide.

The present invention provides processes and intermediates for the preparation of aminoethoxybenzyl alcohols of Formula I useful in the production of pharmaceutically useful compounds 

Processes for the preparation of aminoethoxybenzyl alcohols

It is described a process for preparing (R)-2-bromo-3-phenyl-propionic acid starting from (D)-phenyl-alanine, sodium nitrite and concentrated hydrobromic acid in a mixture of an aqueous solvent and a solvent selected from the group consisting of halogenated hydrocarbons and aromatic hydrocarbons.

Process for preparing (R)-2-bromo-3-phenyl-propionic acid

A process for the preparation of (2S,3S)-threo-2-hydroxy-3-(2-aminophenylthio)-3-(4-methoxyphenyl)-propioni c acid by resolution of the racemic mixture is described. The resolution is carried out by using as resolving agent (1S,2S)-threo-1-phenyl-2-amino-1,3-propanediol or (1S,2S)-threo-1-(4-methylthiophenyl)-2-amino-1,3-propanediol.

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Caldiero, Italy

Giorgio Soriato