Dibra S.p.a.

Bracco International Bv

Bracco S.p.a.

Bracco Imaging S.p.a.

Giorgio Ripa

Maria Argese

Marcella Murru

Alessandro Scala

Carlo Felice Viscardi

Marina Ausonio

Vittorio Valle

Emanuela Panetta

Renato Geremia

Patrizia Cossutta

Chiara Scotti

Giuseppe Manfredi

Fabrizio Rebasti

Marino Brocchetta

Ernst Felder

Enrico Moretti

Andrea Beltrami

Rodolfo Piva

Carlo Distaso

Patrizia Ambrosetti

Laura Alessandroni

Vittorlo Valle

Ernst Fekder

Paolo Morosi

Fulvio Uberti

A process for the preparation of compound of formula (I A), decahydro-2a,4a,6a,8a-tetraazacyclopent[fg]accnaphthylene and the corresponding functionalized compounds of general formula (I), intermediates for the preparation of 1,4,7,10-tetraazacyclododecane (II A) and corresponding derivatives (II), by preparation of compounds of general formula (III) and subsequent reduction thereof.

Process for the preparation of decahydro-2a,4a,6a,8a-tetraazacyclopent[fg]acenaphthylene and functionalized derivatives

1,4,7,10-Tetraazacyclodecane, a precursor for the synthesis of macrocylic chelating agents for metal ions such as gadolinium, is prepared efficiently as a highly pure product on an industrial scale.

Process for the preparation of 1,4,7,10-tetraazacyclododecane

A novel process for the preparation of N,N&prime;-bis&lsqb;2,3-dihydroxypropyl&rsqb;-5-&lsqb;(hydroxyacetyl) methylamino&rsqb;-2,4,6-triiodo-1, 3-benzenedi carboxamide of formula (I), commonly known as lomeprol, a novel non-ionic contrast agent which shows very good safety and contrast effectiveness.

Process for the preparation of n,n'-bis&lsqb;2,3-dihydroxypropyl&rsqb;-5-&lsqb;(hydroxyacetyl) methylamino&rsqb;-2, 4,6-triiodo-1, 3-benzenedi carboxamide

1,4,7,10-tetraazacyclododecane-1,4-diacetic acid

1,4,7,10-tetraazacyclododecane-1,4-diacetic acid derivatives as chelating agents

A process for the preparation of 1,4,7,10-tetraazacyclododecane-1,4,7-triacetic acid and the salts thereof of formula (I) ##STR1## which comprises the following steps: a) carboxymethylation reaction of a suitable precursor in water, with a haloacetic acid,

Process for the preparation of

The present invention relates to the novel compound, 1,4,7,10-tetraazabicyclo[8.2.2]tetradecan-2-one of formula (I), its preparation and the use thereof for the preparation of tetraazamacrocycles . ##STR1##

Process of preparing tetraacetic acid derivatives

Process for the preparation of tetraazamacrocycles

A process for the preparation of tetraazamacrocycles of general formula (I) ##STR1## wherein n, p and q can independently be 0 or 1, comprising the following steps:

The present invention relates to the novel compound, 1,4,7,10-tetraazabicyclo[8.2.2]tetradecan-2-one of formula (I), its preparation and the use thereof for the preparation of tetraazamacrocycles. ##STR1##

Process of preparing tetraaza tetraacetic acid

A process for the preparation of complexes of macrocyclic chelants with paramagnetic metal trivalent ions of formula (XII) ##STR1## wherein R.sub.1, R.sub.2 and Me.sup.3+ are as described in the following, comprising: a) reaction of 1,4,7,10-tetraazacyclododecane with triethyl orthoformate to give 5H,9bH-2a,4a,7,9a-octahydrotetraazacycloocta[cd]pentalene; b) carboxymethylation reaction in water; c) hydrolysis reaction in basic conditions; d) alkylation according to known methods with an epoxide in water; e) complexation according to known methods carried out in water by addition of a paramagnetic metal salt; f) purification by diafiltration, final desalting of the aqueous solution on ion exchange resins and g) crystallization or recovery.

Process for preparation of macrocyclic chelants and the chelates thereof

Process for the preparation of macrocyclic chelants and the chelates

The present invention relates to the novel compound, 1,4,7,10-tetraazabicyclo[8.2.2]tetradecan-2-one of formula (I), its preparation and the use thereof for the preparation of tetraazamacrocycles and the mono and diacetic acid derivatives. ##STR1##

Intermediates

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Milan, Italy

Giorgio Ripa